The Growth Hormone / Insulin-Like Growth Factor Axis during Development

Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.

List of contents

Introduction.- Placenta and early embryonic development.- Experimental models.- Evolution, aging, life span.- Brain development.- Development of sensory organs.- Neuroplasticity and neuroprotection.- Reproductive tract.- Skeletal muscle.- Cardiovascular system-lung.- Hematopoiesis.- Pancreas development and glucose regulation.- IGF interaction with other trophic factors.- Cancer.- Human genetics of the GH-IGF-I axis.- Future perspectives-stem cells.- Index

Summary

Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life.

Product details

• Assisted by: Ann Chowen (Editor), Ann Chowen (Editor), Julie A. Chowen (Editor), Julie Ann Chowen (Editor), Isabe Varela-Nieto (Editor), Isabel Varela-Nieto (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2005
• EAN: 9780387251196
• ISBN: 978-0-387-25119-6
• No. of pages: 422
• Weight: 965 g
• Illustrations: VIII, 421 p.
• Series: Advances in Experimental Medicine and Biology; Advances in Experimental Medicine and Biology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Diabetes, B, Medicine, Neurology, INTERNAL MEDICINE, Endocrinology, Personal & public health, Neurology & clinical neurophysiology, Maternal and child health services, Maternal and Child Health, Materno-fetal medicine