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This book covers the important role small molecules can play in the modulation of stress-activated protein kinase (SAPK), also called the mitogen-activated protein kinase (MAPK) pathway, and the potential this may offer in enabling the development of future medicine therapies. It is clear that MAP kinase pathway therapies could continue to drive increasing interest in the field, both within academic laboratories and also in the biotechnology and pharmaceutical sectors. This book provides an overview of protein kinase inhibitors, the biological roles of MAP kinases, ATP-competitive and non-competitive inhibitors, covalent inhibitors, and more. This book is intended for professors in academia, researchers in pharmaceutical and biotechnology sectors working on protein kinases, and graduate students in pharmacy/chemistry.
List of contents
Chapter 1: Overview of Protein Kinase inhibitors.- Chapter 2: Biological Roles of MAP kinases.- Chapter 3: ATP-competitive inhibitors.- Chapter 4: ATP-noncompetitive inhibitors and Bi-dentate inhibitors.- Chapter 5: Covalent inhibitors.
About the author
Surya Kanta De is a director at Conju-Probe, San Diego, California, USA. Surya K. De obtained his Ph.D. in Organic Chemistry from Jadavpur University, Kolkata (Calcutta), India. He worked at the University of Washington, (Seattle), Purdue University, (West Lafayette, Indiana), the Scripps Research Institute, and Sanford-Burnham Medical Discovery Institute prior to joining a biotech company. He has published over 120 papers in reputed international journals, covering a broad array of specialized topics in science, and he holds fifteen United States and international patents. He has published four solo-authored books. He has been a fellow of the Royal Society of Chemistry (London, UK), the Royal Society of Medicine (London, UK), the American Institute of Chemists (USA), and the Indian Chemical Society. He was a recipient of P. R. Vijayalaxmi Award for Innovation in Cancer Research (2023, USA. He has been an elected councilor at the American Chemical Society since 2022.
