Read more
This book will present the most recent advances in mathematical modeling of nanoparticulate delivery to cancerous lesions. Mathematical modeling and computer simulation of the delivery of therapeutic agents to cancerous lesions is outlined via a discussion of the essential issues, with particular attention to those involving biobarriers. Modeling of various components of drug delivery is carried out, such as tumoral hemodynamics, the covective and brownian diffusion of drug molecules and nanovector within the tumor microcirculation and tumor interstitium, cell resistance mechanisms, diffusion of drug molecules along nanochannels.
List of contents
The Essential Problem: Biobarriers.- The Essential Issues.- A Model of Tumoral-Scale Therapeutics Delivery.- A Model of Cellular-Scale Therapeutics Delivery.- Nanovectors in Drug Delivery and Diagnosis.- Engineering Nanovectors for Optimal Drug Delivery.- Drug Release from Nanochannels
About the author
Mauro Ferrari is a pioneer in the fields of bioMEMS and biomedical nanotechnology. As a leading academic, a dedicated entrepreneur, and a vision setter for the Nation's premier Federal programs in nanomedicine, he brings a three-fold vantage perspective to his roles as Editor-in-Chief for this work. Dr. Ferrari has authored or co-authored over 150 scientific publications, 6 books, and over 20 US andInternational patents. Dr. Ferrari is also Editor-in-Chief of Biomedical Microdevices and series editor of the new Springer series on Emerging Biomedical Technologies.Several private sector companies originated from his laboratories at the Ohio State University and the University of California at Berkeley over the years. On a Federal assignment as SpecialExpert in Nanotechnology and Eminent Scholar, he has provided the scientific leadership for the development of the Alliance for Cancer Nanotechnology of the National Cancer Institute, the world-largest medical nanotechnology operation to date. Dr. Ferrari trained in mathematical physics in Italy, obtained his Master's and Ph.D. in MechanicalEngineering at Berkeley, attended medical school at The Ohio State University, and served in faculty positions in Materials Science and Engineering, and Civil and Environmental Engineering in Berkeley, where he was first tenured. At Ohio State he currently serves as Professor of Internal Medicine, Division of Hematology and Oncology, as Edgar Hendrickson Professor of Biomedical Engineering, and as Professor of Mechanical Engineering. He is Associate Director of the Dorothy M. DavisHeart and Lung Research Institute, and the University's Associate Vice President for Health Science, Technology and Commercialization.
