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Design, Development and Evaluation of Mucoadhesive Nanoemulsion Drugs - Based Drug Delivery System to Deliver Antimigraine Agents. DE

English · Paperback / Softback

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The study aimed to create and assess mucoadhesive nanoemulsion-based drug delivery systems (MNEs) for the effective delivery of antimigraine agents into the central nervous system (CNS). The research investigated three categories of drugs: triptans, beta-blockers, and ACE inhibitors, focusing on their potential to improve therapeutic outcomes for migraine treatment. Drug Selected were Triptans: Sumatriptan, Zolmitriptan, Almotriptan, Beta-Blockers: Propranolol, Timolol, Nadolol, ACE Inhibitors : Captopril, Enalapril, Lisinopril Nanoemulsion FormulationMNEs were prepared using standard nanoemulsion techniques, incorporating mucoadhesive polymers to enhance retention in the nasal cavity.The formulations were evaluated for drug release profiles, mucoadhesive strength, and stability.Results Triptans- Sumatriptan: MNEs showed acumulative drug release of 83.43% after 8 hours.- Zolmitriptan:MNEs exhibited acumulative drug release of 83.63% after 8 hours.- Almotriptan: Demonstrated the highest cumulative drug releaseat89.04% after 8 hours.Overall, MNEs significantly improved drug release for all triptans compared to traditional NEs and plain drug solutions (PDS).

About the author










Dhananjay Mane and his research group are more specifically involved in the development of large variety of catalytic reactions including different principles of green chemistry. His major achievements to explore (i) New Chromatographic method development for forensic science (ii) Synthesis and study of biological active compounds.

Product details

Authors Dhananjay Mane, Mahesh Wagh
Publisher LAP Lambert Academic Publishing
 
Languages English
Product format Paperback / Softback
Released 16.09.2024
 
EAN 9786208064846
ISBN 9786208064846
No. of pages 264
Subject Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry

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