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Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.
List of contents
- The Mitochondrial Free Radical Theory of Aging
Gustavo Barja - Mitochondrial DNA Mutations in Aging
Konstantin Khrapko and Doug Turnbull - Mathematical Models of Mitochondrial Aging and Dynamics
Axel Kowald and Edda Klipp - Mitochondrial Dynamics in Aging and Disease
Jürgen Bereiter-Hahn - The Retrograde Response - A Conserved Compensatory Reaction to Damage from Within and from Without
S. Michal Jazwinski - Mitochondrial Acetylation and Genetic Models of Parkinson's Disease
Georg Auburger, Suzana Gispert and Marina Jendrach - Mitochondrial Dysfunction: Cause and Consequence of Alzheimer's Disease
Kristina Friedland-Leuner, Carola Stockburger, Isabel Denzer, Gunter P. Eckert and Walter E. Müller - Mitochondria in Cancer: Why Mitochondria are a Good Target for Cancer Therapy
Lan-Feng Dong and Jiri Neuzil - Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
Guanghong Jia, Annayya R. Aroor and James R. Sowers - Advances in Development of Rechargeable Mitochondrial Antioxidants
Alexander N. Lukashev, Maxim V. Skulachev, Victoria Ostapenko, Alla Yu. Savchenko, V. V. Pavshintsev and Vladimir P. Skulachev
