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This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.
List of contents
- The Ras superfamily G-proteins
Fuyuhiko Tamanoi - NMR Study to Identify a Ligand-Binding Pocket in Ras
Till Maurer and Weiru Wang - The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
Christian W. Johnson and Carla Mattos - State 1(T) Inhibitors of Activated Ras
Hans Robert Kalbitzer and Michael Spoerner - Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface
Alessandro Di Domizio and Francesco Peri - Development of EHop-016, a Small Molecule Inhibitor of Rac
Suranganie Dharmawardhane - Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
Susanne Schmidt and Anne Debant - Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
Anne Blangy and Philippe Fort - Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
Dominico Vigil and Channing J. Der - A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis - Inhibitors of K-Ras Plasma Membrane Localization
Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock - Ras Chaperons: New Targets for Cancer and Immunotherapy
Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor
