Metal Related Neurodegenerative Disease

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented.

List of contents

1. Editorial: Metal-Related Neurological Disorders: Several New Genes and Better Understanding
Susanne A. Schneider and Kailash P. Bhatia


2. The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations
Kurt A. Jellinger


3. Pantothenate Kinase-Associated Neurodegeneration (PKAN) and PLA2G6-Associated Neurodegeneration (PLAN): Review of Two Major Neurodegeneration with Brain Iron Accumulation (NBIA) Phenotypes
Manju A. Kurian and Susan J. Hayflick


4. Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN)
Monika Hartig, Holger Prokisch, Thomas Meitinger and Thomas Klopstock


5. BPAN: The Only X-Linked Dominant NBIA Disorder
Tobias B. Haack, Penny Hogarth, Allison Gregory, Holger Prokisch and Susan J. Hayflick


6. Neuroferritinopathy
Michael J. Keogh, Christopher M. Morris and Patrick F. Chinnery


7. Aceruloplasminemia-An Update
Satoshi Kono


8. Therapeutic Advances in Neurodegeneration with Brain Iron Accumulation
Giovanna Zorzi and Nardo Nardocci


9. The Neuropathology of Neurodegeneration with Brain Iron Accumulation
Michael C. Kruer


10. Imaging of Iron
Petr Dusek , Monika Dezortova and Jens Wuerfel


11. The Role of Iron Imaging in Huntington's Disease
Simon J. A. van den Bogaard, Eve M. Dumas and Raymund A.C. Roos


12. Lysosomal Storage Disorders and Iron
Jose Miguel Bras


13. Manganese and the Brain
Karin Tuschl, Philippa B. Mills and Peter T. Clayton


14. Update on Wilson Disease
Annu Aggarwal and Mohit Bhatt


15. An Update on Primary Familial Brain CalcificationRoberta R. Lemos, J. B. M. M. Ferreira, Matthew P. Keasey and Joao R. M. Oliveira

Product details

• Assisted by: Kailash P Bhatia (Editor), Susanne Schneider (Editor)
• Publisher: Elsevier Science & Technology
• Languages: English
• Product format: Hardback
• Released: 11.11.2013
• EAN: 9780124105027
• ISBN: 978-0-12-410502-7
• Dimensions: 152 mm x 24 mm x 229 mm
• Weight: 780 g
• Series: International Review of Neurobiology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; MEDICAL / Neurology, Neurology & clinical neurophysiology, Neurology and clinical neurophysiology