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This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.
List of contents
1. Metal ion physiology: Mechanistic approach
Svetlana Lutsenko
2. Transferrin mediated iron uptake
Anne B. Mason
3. Structure-function of siderophore-iron transporters
Isabelle J. Schalk
4. Iron transport machinery of human cells: players and their interactions
Caroline A. Enns
5. Mechanism of copper uptake in mammalian cells
Vinzenz Unger and Jack H. Kaplan
6. Heavy metal transport P-type ATPases
Amy C. Rosenzweig and Jose Argüello
7. CUS periplasmic Cu+ efflux system
Ninian J. Blackburn and Megan McEvoy
8. Molecular architecture and function of ZnT transporters
Taiho Kambe
9. Structure-function of ZIP transporters
Robert E. Dempski
10. Nramp family of transporters
Mathieu F. Cellier
11. Plant YSL metal transporters
Elsbeth Walker and Sarah S. Conte
12. Pathways of arsenic uptake and detoxification
Barry P. Rosen
13. Mechanisms of heme transport and trafficking
Angela Wilks
14. Mechanisms of Mg2+ and Co2+ transport
Said Eshaghi
