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Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.
After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.
List of contents
1. Barriers to Gene and Protein Delivery
2. Gene Delivery Using Physical Methods
3. Gene Delivery Using Chemical Methods
4. Gene Delivery Using Viral Vectors
5. RNA based therapeutics
6. Protein and Peptide Delivery through Respiratory Pathway
7. Oral Delivery of Proteins and Peptides: Concepts and Applications
8. Parenteral Delivery of Peptides and Proteins
9. Other Routes of Protein and Peptide Delivery: Transdermal, Topical, Uterine, and Rectal
10. Computational tools in genomics and proteomics
11. CRISPR/Cas9 gene-editing for treating gene and protein disorders
12. Regulatory guidance on therapeutic proteomics and genomics
