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Cholinergic Involvement in Neurodegenerative Diseases, Volume 211 reviews cholinergic function in the brain as it relates to Neurodegenerative disorders. Coverage includes Alzheimer’s, dementia, Down Syndrome, Parkinson’s, Huntington’s, ALS, and more. In addition, the anatomy of the cholinergic system is described as well as the distribution and function of receptors.
List of contents
1. The history of the CNS cholinergic transmission
2. Organization of the basal forebrain cholinergic system in the human brain
3. The cholinergic synapses
4. Nicotinic acetylcholine receptors in the brain
5. Cognition and modulation of the cholinergic system
6. The involvement of the cholinergic system in Alzheimer disease
7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology
8. The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology
9. NGF based cholinergic therapies in Alzheimer disease
10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission
11. Cholinergic therapy in Alzheimer’s disease
12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment
13. The Cholinergic system in down syndrome
14. The Cholinergic system in Parkinson disease
15. The Cholinergic system in dementia with Lewy bodies
16. Epilogue. Standing on the shoulders of giants-Charting the future of cholinergic research
About the author
A. Claudio Cuello works in the Department of Pharmacology and Therapeutics at McGill University in Montreal, Quebec, Canada.
