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Informationen zum Autor JIE JACK LI is a medicinal chemist at Pf izer Global Research and Development in Ann Arbor, Michigan. His research interests include medicinal chemistry, heterocyclic chemistry, transition metal-catalyzed reactions, and radical chemistry. He is author of Name Reactions: A Collection of Detailed Reaction Mechanisms , and coauthor of Palladium in Heterocyclic Chemistry and Contemporary Drug Synthesis , also published by Wiley. Klappentext Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors-some of whom have discovered the very reactions they describe- Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike. Zusammenfassung Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information! it is often a difficult topic to cover for undergraduate and graduate chemistry students! even in simplified form. Inhaltsverzeichnis Foreword x Preface xi Acronyms and abbreviations xiv Part 1 Three- And Four-Membered Heterocycles 1 Chapter 1 Epoxides and Aziridines 1 1.1 Corey-Chaykovsky reaction 2 1.2 Darzens glycidic ester condensation 15 1.3 Hoch-Campbell aziridine synthesis 22 1.4 Jacobsen-Katsuki epoxidation 29 1.5 Paterno-Büchi reaction 44 1.6 Sharpless-Katsuki epoxidation 50 1.7 Wenker aziridine synthesis 63 Part 2 Five-Membered Heterocycles 69 Chapter 2 Pyrroles and Pyrrolidines 69 2.1 Barton-Zard reaction 70 2.2 Knorr and Paal-Knorr pyrrole syntheses 79 2.3 Hofmann-Löffler-Freytag reaguo 90 Chapter 3 Indoles 99 3.1 Bartoli indole synthesis 100 3.2 Batcho-Leimgruber indole synthesis 104 3.3 Bucherer carbazole synthesis 110 3.4 Fischer indole synthesis 116 3.5 Gassman indole synthesis 128 3.6 Graebe-Ullman carbazole synthesis 132 3.7 Hegedus indole synthesis 135 3.8 Madelung indole synthesis 140 3.9 Nenitzescu indole synthesis 145 3.10 Reissert indole synthesis 154 Chapter 4 Furans 4.1 Feist-Bénary furan synthesis 160 4.2 Paal-Knorr furan synthesis 168 Chapter 5 Thiophenes 183 5.1 Fiesselmann thiophene synthesis 184 5.2 Gewald aminothiophene synthesis 193 5.3 Hinsberg synthesis of thiophene derivatives 199 5.4 Paal thiophene synthesis 207 Chapter 6 Oxazoles and Isoxazoles 219 6.1 Clais...
