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Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners.
Firsthand accounts of each project tell of the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges.
This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.
List of contents
Preface, Michael Harmata
1. Acortatarin A: Spiroketalization Methods and Synthesis, Barry B. Butler, Jr. and Aaron Aponick
2. Devising New Syntheses of the Alkaloid Galanthamine, a Potent and Clinically Deployed Inhibitor of Acetylcholine Esterase, Martin Banwell, Joshua Buckler, Colin J. Jackson, Ping Lan, Xinghua Ma, Eliska Matousová and Jeremy Nugent
3. Discodermolide: Total Synthesis of Natural Product and Analogs, Jean-François Betzer
4. A Walk across Total Synthesis of Mycolactone Analogs - Mechanistic Implications in Mycobacterium ulcerans Infection, Nicolas Blanchard
5. Total Synthesis of the Fungal Metabolite Virgatolide B, Paul A. Hume, Daniel. P. Furkert and Margaret A. Brimble
6. The Role of Serendipity and Design in the Development of Oxidative Coupling Reactions, Brenton DeBoef
7. Overcoming Electronics with Strategy: Development of an Efficient Synthesis of a Novel Antiretroviral, BMS-663068, Ke Chen, Christina Risatti and Martin Eastgate
8. Synthesis of Alkaloids Containing a Quinolizidine Core by Means of Strategies Based on a Hydroformylation Reaction, Nicolas Girard
9. Total Synthesis of Sorbicillactone A: An Inspiration for Methodology and Catalyst Development, Kelly A. Volp and Andrew Harned
10. Total Synthesis of (-)-7-Deoxyloganin exploiting N-Heterocyclic Carbene Catalysis with ?,?-Unsaturated Enol Esters, Lisa Candish and David W. Lupton
11. The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol, Cristian Draghici and Jon T. Njardarson
12. Total Synthesis of Communesin F and Perophoramidine, Dan Zhang, Hao Song and Yong Qin
