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Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of ? -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures.
Drawing on the author's expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of ? -glucosidase inhibitor chemistry and activity.
List of contents
1. Introduction
2. Natural Alpha-Glucosidase Inhibitors: Sugar Mimics
3. Natural Chalcone Glucosides, Flavonoids and Xanthones
4. Cyclitols, Alkaloids, Curcuminoids and Curcumin Analogs
5. Terpenes, Steroids and Other Natural Derivatives
6. Synthetic Alpha-Glucosidase Inhibitors: Sugar Mimics
7. Chalcones and Xanthone Derivatives
8. Cyclitol Derivatives
9. Thiadiazoles and Other Derivatives
Appendix: Complete list of promising alpha-glucosidase inhibitors with their activity data discussed in this book
