Viral Replication Enzymes and their Inhibitors Part A

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

List of contents

Preface
Craig E. Cameron, Jamie J. Arnold and Laurie S. Kaguni
1. CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis
Brandon Malone, Seth A. Darst and Elizabeth A. Campbell
2. Mechanisms of inhibition of viral RNA replication by nucleotide analogs
Kenneth A. Johnson and Tyler Dangerfield
3. HCV RdRp, sofosbuvir and beyond
Joy Y. Feng and Adrian S. Ray
4. Understanding viral replication and transcription using single-molecule techniques
Emmanuelle Pitre and Aartjan J.W. te Velthuis
5. In vitro single-molecule manipulation studies of viral DNA replication
Rebeca Bocanegra, Ismael Plaza-G.A. and Borja Ibarra
6. Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity
Dennis S. Winston and David D. Boehr
7. Single-cell analysis for the study of viral inhibitors
Mohamad S. Sotoudegan, Jamie J. Arnold and Craig E. Cameron
8. Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses
Peng Gong
9. Picornaviral 2C proteins: A unique ATPase family critical in virus replication
Pu Chen, Zhijian Li and Sheng Cui
10. Flavivirus enzymes and their inhibitors
Ekaterina Knyazhanskaya, Marc C. Morais and Kyung H. Choi
11. Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-Ray crystallography
Yeonoh Shin and Katsuhiko S. Murakami
12. Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
Kieran Maheden, Brendan Todd, Calvin J. Gordon, Egor P. Tchesnokov and Matthias Götte

Product details

• Assisted by: Jamie J. Arnold (Editor), Craig E. Cameron (Editor)
• Publisher: Elsevier Science & Technology
• Languages: English
• Product format: Hardback
• Released: 22.10.2021
• EAN: 9780128234686
• ISBN: 978-0-12-823468-6
• Dimensions: 152 mm x 20 mm x 229 mm
• Weight: 700 g
• Series: The Enzymes
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / General, SCIENCE / Life Sciences / Biology, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Molecular Biology, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Life Sciences / Biophysics, biochemistry, molecular biology, Biology, life sciences, Life sciences: general issues, Cellular biology (cytology), Biophysics