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Adenoviral Vectors for Gene Therapy, Third Edition, provides detailed, comprehensive coverage of gene delivery vehicles based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, as platforms for gene therapy and gene editing, as well as for oncology approaches, making them class leading agents in the gene-advanced therapies arena.
The fully updated and expanded third edition covers the basic biology of adenoviruses and highlights the potential use of adenoviral vectors for the treatment of disease, including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for veterinary applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine applications, and oncolytic adenoviruses for antitumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.
List of contents
1. Structural Biology of Adenovirus
2. Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms
3. Adenovirus Replication
4. Adenoviral Vector Construction I: Mammalian Systems
5. Adenoviral Vector Construction II: Bacterial Systems
6. Adenoviral Vector Packing Cell Lines
7. Purification of Adenovirus
8. Innate Immune Response to Adenovirus
9. Antibodies to Adenovirus
10. Methods to Mitigate Immune Response
11. Xenogenic Adenoviral Vectors as Vaccines
12. Adenoviral Vector Targeting
13. Helper-Dependent Adenovirus
14. Hybrid Adenoviral Vectors
15. Canine Adenovirus
16. Oncolytic Adenovirus
17. Imaging Analysis
18. Adenoviral Vaccines - Cancer
19. Adenoviral Vaccines - Infectious Disease
20. Adenoviral Vaccines - COVID 19
21. Adenoviral Vectored Veterinary Vaccines
22. Utility of Adenoviral Vectors in Animal Models - CV Disease
23. Utility of Adenoviral Vectors in Animal Models - Pulmonary Disease
24. Utility of Adenoviral Vectors in Animal Models - Genetic Disease
25. Adenoviral Vectors for Gene Editing
26. Manufacturing and Upscaling
27. Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective
