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Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.
List of contents
1. An overview on colonic diseases
2. Colonic disease - targeting strategies
3. Nanocarriers for the colonic diseases
4. Applications of nanocarriers in colon targeting
5. Polymeric nanoparticles in colon targeting
6. Polymersomes in colon targeting
7. Polymeric micelles in colon targeting
8. Solid lipid nanoparticles in colon targeting
9. Nanostructured lipid carriers in colon targeting
10. Liposomes in colon targeting
11. Carbon-based nanomaterials in colon targeting
12. Gold nanoparticles in colon targeting
13. Supramagnetic iron oxide nanoparticles for colon targeting
14. Magnetic triblock copolymer nanoparticles in colon targeting
15. Dendrimer nanoparticles for colon targeting
16. Mesoporous silica nanoparticles in colon targeting
17. Redox nanoparticles in colon drug targeting
18. Protein and peptides-based nanoparticles in colon targeting
19. Hybrid nanoparticles in colon targeting
20. Polysaccharides Based nanocarriers in colon targeting
21. Nanocrystals based approach in colon targeting
22. Nano-based enema’s for colon targeting
23. Exosomes in colon targeting
24. Pre-clinical and clinical status of different nanocarriers for colon targeting
25. Regulatory issues and toxicological concerns related to nanocarriers
About the author
Lalit Kumar is an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, Bihar, India. His area of research includes the development of nanocarriers for drug-targeting tumor cells in the colon, brain, breast, and lungs.Yashwant Pathak is a Professor and Associate Dean for faculty affairs at the Taneja College of Pharmacy at the University of South Florida, Tampa, USA. Prof. Pathak is also an Adjunct Professor at the Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia. His area of research is in health care education, nanotechnology, drug delivery systems, and nutraceuticals.
