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This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients.
The book provides readers with information on key fundamental concepts of CAR-T manufacturing in areas such as cell selection, cell activation, cell transfection, cell expansion, genetic engineering, and quality control. In each chapter, a particular technological field in the CAR-T manufacturing chain is discussed. Each chapter will include an introduction to the importance of a particular technology for cell manufacturing, comparisons of state-of-the-art methods, and discussions on respective emerging innovations. This exposes readers to a high-level view of the entire process while diving into details for each specific process step. Readers will be able to apply their knowledge to make changes at each step of the CAR-T manufacturing process to reduce the existing high costs and long production times, so that cancer patients globally can benefit from CAR-T therapy.
This book is an invaluable resource for practitioners in CAR-T manufacturing who aim to improve their quality and efficiency while reducing time and costs. It is also useful for advanced undergraduate and graduate students who wish to gain a strong foundation for continuing research in the field or interacting with practitioners.
List of contents
1. Immune cell selection and Isolation 2. Strategies for T cell Activation 3. Genetic tools to engineer CAR-T cells: Lessons from clinical studies 4. Intracellular delivery methods for therapeutic immune T-cell engineering 5. Bioreactor technology for CAR T cell manufacturing 6. Quality Control of CAR-T Products 7. Advances for in vivo CAR-T manufacturing
About the author
Andy Tay is a Presidential Young Professor in the Department of Biomedical Engineering at the National University of Singapore (NUS) and Principal Investigator at the Institute of Health Innovation & Technology and NUS Tissue Engineering Programme. He obtained his Bachelor's degree from NUS and his PhD from UCLA in 2014 and 2017, respectively.
Summary
This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients.
