Tic Disorders and Tourette Syndrome

Tic Disorders and Tourette Syndrome is an essential resource that delves into the clinical aspects, treatments, and ongoing research related to tic disorders and Tourette syndrome. It covers a range of topics from primary to secondary and functional tics, providing differential diagnosis. The book is designed to offer foundational knowledge to neurologists, psychiatrists, neuropsychiatrists, and psychologists, while also catering to the needs of advanced readers. In addition to clinical presentations, the book discusses the epidemiology, etiology, and pathophysiology of tics, along with common neuropsychiatric comorbidities such as obsessive-compulsive disorder, ADHD, mood disorders, and intermittent explosive disorder.

The volume also includes treatment options and clinical scales to evaluate tics, illustrated with video accompaniments and animal models.

List of contents

1. Introduction
2. Georges Gilles de la Tourette in the history of tics

Section 1. Clinical Diagnosis of Tics
3. Clinical presentation of tics and Gilles de la Tourette syndrome
4. Secondary Tics: Etiology, presentation and management
5. Functional tics and tic-like behaviors
6. Repetitive and restricted behaviors, habits, body-focused repetitive behaviors and motor stereotypies

Section 2. Comorbidities in Primary Tic Disorders
7. OCD in primary tic disorders and Tourette syndrome
8. Attention-deficit/hyperactivity disorder in primary tic disorders and Tourette Syndrome
9. Explosive outbursts and Tourette Syndrome/Chronic tic disorder
10. Sleep in tic disorders and Tourette Syndrome
11. Autism spectrum and other neurodevelopmental disorders
12. Sexuality and sexual health in primary tic disorders

Section 3. Etiology and Pathophysiology
13. Epidemiology of Tourette Syndrome
14. Genetics of tic disorders and Tourette Syndrome
15. Neuroimmunology of tics and Gilles de la Tourette syndrome
16. Animal models of Gilles de la Tourette syndrome and other tic disorders
17. Clinical neurophysiology of tics
18. Neuroimaging of tic disorders
19. Dopamine and other neurotransmitters
20. Premonitory urges and other sensory phenomena in primary tic disorders
21. Inhibitory control and voluntary tic suppression

Section 4. Treatments
22. Behavioral treatments of tic disorders
23. Pharmacological treatments
24. Deep brain stimulation for Gilles de la Tourette syndrome
25. Non-invasive brain stimulation for Gilles de la Tourette syndrome
26. Treatment of neuropsychiatric comorbidities in tic disorders

Section 5. Overview of patient organizations and other useful resources
27. Overview of support associations and other useful resources

Section 6. Closing Remarks and Future
28. Closing remarks and future scope of unmet needs

About the author

Dr. Christos Ganos is an active staff neurologist within UHN’s Krembil Brain Institute at Toronto Western Hospital and an associate professor in the Division of Neurology at the University of Toronto. He also holds the Wolf Family Chair in Neurodevelopmental Psychiatry.
Born in Thessaloniki, Greece, he completed his medical training at the University Medical Center in Hamburg - Eppendorf in Germany, undertook a three-year fellowship at the National Hospital for Neurology and Neurosurgery, and from 2017 to 2023 was a consultant at the Movement Disorder Unit of the Charité Hospital, Berlin.
Dr. Ganos has expertise in hyperkinetic, neuropsychiatric and unusual or rare movement disorders, including tic disorders, Huntington’s disease and the Ataxia programs. His research focuses on the characterization of clinical phenomena and the elucidation of their pathophysiological origin.
He served as the founding chair of both the International Parkinson and Movement Disorder Society’s (MDS) Study Group and Task Force on Tic Disorders and Tourette Syndrome, and was a past secretary of the European Society for the Study of Tourette Syndrome (ESSTS).
Yulia Worbe is a tenured Professor of Clinical Neurophysiology at Sorbonne University and serves as a consultant neurophysiologist and neurologist at Sorbonne University Hospitals, primarily at Pitié-Salpêtrière and Saint-Antoine. She specializes in the neurophysiology of movement disorders and has a longstanding interest in Tourette syndrome.
Dr. Worbe graduated from the Medical University of St. Petersburg, Russia, where she completed her general neurology training. She subsequently specialized in movement disorders at Pitié-Salpêtrière Hospital in Paris. Her research on Gilles de la Tourette syndrome led to a PhD in Neuroscience from Sorbonne University, where she developed animal models of Tourette disorder.
She completed two post-doctoral fellowships: one at Sorbonne University, focusing on basal ganglia and network dysfunction in Tourette disorder using neuroimaging, and another at the University of Cambridge's Behavioural and Clinical Neuroscience Institute, exploring serotonergic regulation of behavior using brain imaging.
Prof. Worbe’s research centers on the cognitive and behavioral aspects of movement disorders, with a focus on Gilles de la Tourette syndrome and genetic dystonia. She investigates brain function in these disorders using cognitive testing, neuroimaging, and non-invasive neurostimulation techniques.

Product details

• Assisted by: Christos Ganos (Editor), Yulia Worbe (Editor)
• Publisher: Elsevier
• Languages: English
• Release: 01.01.2026
• EAN: 9780443135545
• ISBN: 978-0-443-13554-5
• Series: Handbook of Clinical Neurology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; SCIENCE / Life Sciences / Neuroscience, MEDICAL / Pathology, Pathology, MEDICAL / Neuroscience, MEDICAL / Neurology, Neurology & clinical neurophysiology, Neurosciences, Neurology and clinical neurophysiology,

  Tic disorders; Tourette Syndrome; neuropsychiatry