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Sickle cell disease is a complex disease with a genetic mutation producing a wide variety of manifestations. It is of great public health importance nationally and internationally. While the conclusions of this study support the generally accepted views on the disease, the book provides the most recent information and state-of-the-art knowledge on the subject. The book is unique in that it presents the genetic, molecular, cellular, metabolic, rheologic, clinical, diagnostic, therapeutic, and psychosocial dimensions of sickle cell disease. Its synthesis of micro to macro, molecular to cellular, individual to social relationships provides a comprehensive study of sickle cell disease.
The book offers a synthesis of basic science describing genetic, molecular, metabolic, and rheologic aspects of sickle cell disease. Clinical aspects, including diagnosis and treatment, and psychosocial aspects, covering the interaction of the patient with sickle cell disease with society, are also treated. Physicians, scientists, allied health workers, sociologists, and social workers, epidemiologists and anthropologists as well as administrators of sickle cell centers will find this volume useful. The ultimate goal of the book is to improve the understanding of sickle cell disease and to contribute to a better quality of life for those who have the disease or who are at risk of getting it.
List of contents
Preface
Introduction: Epidemiology and Population Genetics of Sickle Cell Disease and the Sickle Cell Trait by Vipul N. Mankad and Charles Hoff
Basic Science Aspects of Sickle Cell DiseaseMolecular Aspects of Polymerization of Hemoglobin by A. Seetharama Acharya
Pathophysiology of the Sickle Cell by R. Blaine Moore
Interactions of Blood Cells and Vascular Endothelium in Sickle Cell Disease: Eicosanoids as Signals and Modulators by Gesina L. Longenecker
Anatomical Lesions in Sickle Cell Hemoglobinopathies by Lemuel W. Diggs
Clinical Diagnosis and Management of Sickle Cell DiseaseDiagnosis of Sickle Cell Disease and Its Related Hemoglobinopathies Disorders by Yih-Ming Yang, Susan Brigham, and Paul I. Liu
Screening for Sickle Cell Disease by Yih-Ming Yang and Paul I. Liu
Hematological Manifestations of Sickle Cell Disease by Vipul N. Mankad
Conventional and Experimental Approaches to Management of Acute Vaso-Occlusive Pain (Painful Crises) by Lennette J. Benjamin
Infection in Sickle Cell Disease by Marilyn H. Gaston and Clarice D. Reid
Neurological Complications of Sickle Cell Disease by Vipul N. Mankad and Paul R. Dyken
Hepatobiliary, Renal, and Pulmonary Complications in Sickle Cell Disease by Vipul N. Mankad and Yih-Ming Yang
Radiological Implications of Sickle Cell Disease by B. Gil Brogdon, Myron L. Lecklitner, Byron C. Machen, and John Powell Williams
Anesthetic Management of Patients with Sickle Cell Disease by Aparna V. Mankad
Surgical Management of Patients with Sickle Cell Syndromes by John P. Sutton, John J. Farrer, and Charles B. Rodning
Psychosocial Aspects of Sickle Cell DiseaseDiagnosis and Management of Psychosocial Problems in the Sickle Cell Disease Patient and Family by Kermit B. Nash
Bibliography
Index
About the author
VIPUL N. MANKAD, a physician scientist and a pediatric hematologist-oncologist, is Louise Lenoir Lock Distinguished Professor and Vice Chairman of Pediatrics. He is a Senior Scientist at the Comprehensive Sickle Cell Center at the University of South Alabama College of Medicine.
R. BLAINE MOORE, a biochemist and red cell scientist is an Associate Director and a Scientist at the Comprehensive Sickle Cell Center at the University of South Alabama College of Medicine. He is also an Associate Professor of Pediatrics and Biochemistry at South Alabama.
