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Natural products are a marvel of evolution. Plants are chemical factories and have produced a vast number of highly diverse and interesting natural substances with their extraordinary properties, which we humans have been using for centuries to relieve and cure diseases. At the latest since the discovery of penicillin, natural substances have become an important source of medicines, but we know only very few of the presumably many millions that are still waiting to be discovered. Important antibiotics, immunosuppressants, anticancer agents, hormones, and antiviral agents are among the natural products. But do natural products still matter in the age of biotechnology and genetic engineering? Yes, more than ever, because medicinal chemists draw creative inspiration for their syntheses from nature to develop the next blockbuster in medicine.
Oliver Kayser tells the story of natural products and medicinal plants in this book in a highly informative and amusing way from a new perspective. He explores how natural products from naturopathy gave birth to the pharmaceutical industry, how they shaped our society as medicines and remedies, enabled wars, and paved the way to Nobel Prizes. The author paints a fascinating panorama of natural product chemistry in plants, microorganisms, and animals. Starting with the first isolations at the beginning of the industrial revolution, he leads us with the ideas and enthusiasm of many scientists into the modern era of drug testing, computer chemistry, and the highly successful serendipitous discoveries of active ingredients. Natural product research in the laboratory has an enormous impact on our lives today. The author offers a glimpse over the shoulder of how the search for the new drugs of tomorrow works today. This book is the ultimate book from the pen of a scientist deeply rooted in research, providing the reader with an enlightening and at the same time entertaining insight into how scientists think and how arduous research can be.
List of contents
Morphine - the Gift of Morpheus.- Cocaine - from Drug to Local Anesthetic.- Aspirin - the Most Used Medicine in Human History.- Steroids and the Pill.- Caffeine and Viagra.- Quinine.- Coumarins - from Rat Poison to Medicine for the President.- Natural Products as Starting Materials for Drug Synthesis.- Modern Drug Research.- Are Drugs Only Bad?.- Healing Poisons.
About the author
Oliver Kayser is a pharmacist, internationally recognized professor, and natural product researcher at TU Dortmund. He is the author of many scientific publications and textbooks. His great interest lies in medicinal plants and natural products that have fostered the birth of modern drugs. The focus of his work is on researching the biosynthesis of medically significant natural products in plants, which today serve as lead structures for new active ingredients in cancer medicine, neurological diseases, and as antibiotics.
