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Zusatztext "As this volume so capably demonstrates! genetic variation in cytokines! the messengers of the immune system! and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge! techniques as well as informed speculation?The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."- From the foreword by Grant Gallagher and Michael F. Seldin! Editors! "Genes and Immunity"! March 2006 Informationen zum Autor Koen Vandenbroeck Klappentext Written by the leading specialists! this book brings together! reviews! and structures up-to-date information on polymorphisms in cytokine genes. While the beginning chapters discuss the properties of individual cytokines! in the later chapters cytokine polymorphisms are re-presented considering the individual disease or condition. Broadening understanding of the effect of genetic variations on human immune responses! the organization! scope! and content of this book make it a valuable and easily accessible resource. A reference for geneticists! immunologists! cell and molecular biologists and clinicians! the book is a must for everyone involved in! or planning! cytokine genetics or immunogenetics studies. Zusammenfassung Offers information on polymorphisms in cytokine genes. This book discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. It documents polymorphisms in the most important cytokine genes, or gene clusters. Inhaltsverzeichnis GENERAL CONCEPTSThe Biology of Cytokines:General Principles! Properties and Lessons from Animal Models! D. Agnello and M. GadinaGenetics of Multifactorial Disorders! J.R. Oksenberg and J.D. RiouxStatistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions! A. Goris and M. de AndradeIntroduction to Integrated Bioinformatic Resources for Cytokine Genetics Research! R. LazarusCytokine Gene Nucleotide Sequence Alignments! J. BidwellSNP Genotyping Techniques! P.-Y. KwokCYTOKINE GENE POLYMORPHISMS The IL1 Cluster! T. Pessi! C. Eklund! A. Raitala! and M. HurmeIL-2 Biology and Polymorphisms in Multifactorial Conditions! F. Matesanz! M. Fedetz! and A. AlcinaThe Chromosome 5q23.1 -q31.1 Cluster of Cytokines! T. LaitinenIL10! R. LazarusThe IL19 Subfamily of Cytokines! S. Kõks! K. Kingo! E. Vasar! and H. SilmThe IFNG -IL26 -IL22 Cytokine Gene Cluster! K. Vandenbroeck and A. GorisTNF-a Polymorphisms and Disease! R.M. Gorczynski and I. BoudakovMacrophage Migration Inhibitory Factor (MIF)! Z. Alourfi! D.W. Ray! and R. DonnPolymorphisms of Chemokines and Their Receptors! B. Puissant! C. Combadière! and E. LavergnePOLYMORPHIC CYTOKINE NETWORKS IN MULTIFACTORIAL CONDITIONSAsthma and Atopy! J. Karjalainen! M. Virta! K. Ädjers! and M. HurmeCommon Rheumatic Diseases! R. Kilding and A.G. WilsonSystemic Lupus Erythematosus! S. D 'AlfonsoSjögren 's Syndrome! M. PertovaaraMultiple Sclerosis! O.H. Kantarci and B.G. WeinshenkerType 1 and 2 Diabetes! R. Bergholdt and F. PociotPsoriasis! S. Kõks! K. Kingo! E. Vasar! and H. SilmDiseases of the Gastrointestinal Tract! T. HöhlerPulmonary Fibrosis! B. Yucesoy and M.I. LusterAtherosclerosis! G. Candore! S. Vasto! G. Colonna-Romano! D. Lio! M. Carusob! I.M. Rea! and C. CarusoLongevity! I.M. Rea! G. Candore! L. Cavallone! F. Olivieri! M. Cardelli! C. Franceschi! G. Colonna-Romano! D. Lio! O.A. Ross! and C. CarusoAIDS! A. Vasilescu! H. Do! and J.-F. ZaguryTropical Infectious Diseases! T. Quirico-Santos! A.M. Da-Cruz! C. Fernandez Kubelka! J. Lannes-Vieira! and M. Ozório MoraesSuseptibility to Infection and Severe Disease in Schistosomiasis! V. Arnaud and C. ChevillardIndex ...
