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In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results.
Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application?
List of contents
From the contents:
Preface.- List of Contributors.- Section I: Different Cell Types for Possible use in Transplantation.- Section II: Biological Mechanisms Concerning Transplanted Cells.- Section III: Mechanisms Concerning Repopulation of the Normal and Diseased Liver.- Section IV: Cell Therapy of Acute Liver Failure and Chronic Liver Disease.- Section V: Cell Therapy for Genetic Liver Diseases.- Section VI: Additional Considerations in Clinical Applications.- Index.
Summary
The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells.
