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Dieses Handbuch der Arteriosklerose mit Beiträgen ausgewiesener Experten hebt die Rolle spezifischer Mediatoren für die Entwicklung von Plaques hervor. Dabei konzentriert es sich sowohl auf die molekularen Mechanismen, die der Erkrankung zugrunde liegen, als auch auf potenzielle Angriffspunkte für neuartige Medikamente. Mit übersichtlichen Tabellen und Abbildungen.
List of contents
INTRODUCTION
PATHOGENESIS OF ATHEROSCLEROSIS. Sarah George & Cressida Lyon
PROINFLAMMATORY FACTORS
CHEMOKINES AND ATHEROSCLEROSIS: A CRITICAL ASSESSMENT OF THERAPEUTIC TARGETS. Gemma White, Keith Channon & David Greaves
ADHESION MOLECULES AND ATHEROSCLEROSIS Huan Wang & Yuqing Huo
CYTOKINES AND ATHEROSCLEROSIS. Alain Tedgui, Hafid Ait-Oufella and Ziad Mallat
TOLL-LIKE RECEPTORS IN ATHEROSCLEROSIS Zhong-qun Yan, Kristina Edfeldt & Anna Lundberg
PPAR-BASED THERAPIES FOR THE MANAGEMENT OF ATHEROSCLEROSIS Florence Gizard & Inés Pineda-Torra
PENTRAXINS IN VASCULAR PATHOLOGY: THE ROLE OF PTX3. Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Fabiola Molla & Roberto Latini
PROTEASES
METALLOPROTEINASES, THE ENDOTHELIUM AND ATHEROSCLEROSIS Stephen White & Andrew Newby
CATHEPSINS IN ATHEROSCLEROSIS Lili Bai, Esther Lutgens & Sylvia Heeneman
THE PLASMIN SYSTEM AND ATHEROSCLEROSIS Chris Jackson & Kevin Carson
MAST CELL PROTEASES AND ATHEROSCLEROSIS Petri Kovanen
HYPERLIPIDEMIA
MACROPHAGE FOAM CELL FORMATION: THE PATHWAYS TO CHOLESTEROL ENGORGEMENT. Kathryn Moore & Katey Rayner
OXIDATIVE STRESS
NADPH OXIDASE AND ATHEROSCLEROSIS Jamie Jeremy, Saima Muzaffar, Carina Mill & Nilima Shukla
UNCOUPLING OF ENDOTHELIAL NITRIC OXIDE SYNTHASE IN ATHEROSCLEROSIS. Colin Cunnington & Keith Channon
HEME OXYGENASE-1 AND ATHEROSCLEROSIS Justin Mason & Faisal Ali
CELL GROWTH AND PHENOTYPE
PHENOTYPIC HETEROGENEITY OF SMOOTH MUSCLE CELLS. IMPLICATIONS FOR ATHEROSCLEROSIS Marie-Matteo Coen and Luce Bochaton-Piallat
PLATELETS: THEIR ROLE IN ATHEROGENESIS AND THROMBOSIS IN CORONARY ARTERY DISEASE. Matthew Harper, Lucy MacCarthy-Morrogh, Matthew Jones, Olga Konopatskaya & Alastair Poole
MODULATORS OF MONOCYTE AND MACROPHAGE PHENOTYPES IN ATHEROSCLEROSIS Nick Jenkins & Jason Johnson
Report
"This book [is] especially interesting for researchers in the pharmaceutical industry...also for those with more experience which will benefit from the summary of the last findings in the field." ( RoSearch , December 2010)
