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Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities.
This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives.
It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
List of contents
1. Introduction to caspases, its function, mechanism, and classification
Sushanta Bhattacharya, Shankar Gupta and Vivek Asati
2. Mutations within apoptosis gene and caspases
Manya Khurana, Paranjeet Kaur, Somdutt Mujwar, Manjinder Singh and Sanjeev Kumar Sahu
3. Inflammatory caspase-1, -4, and -5 and their role in anticancer activity
Ruchi Shakya, Navneesh, Shivanshu Pandey, Sumit Pasricha, Balak Das Kurmi and Preeti Patel
4. Caspase-2 and tumor suppression
Ravindra Kumar Chourasiya, Ankur Vaidya and Alok Nahata
5. Caspase-3: A promising target for anticancer agents
Sushmita Pandey, Shweta Jain, Sanjeev Sahu, Vinod Gurjar and Ankur Vaidya
6. Caspase 7 mutations and their activators
Sanjeev Kumar Sahu, Charanjit Kaur, Ankit Yadav, Yashraj Potale, Paranjeet Kaur, Shweta Jain and Ankur Vaidya
7. Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy
Vinod Kumar Gurjar, Shweta Jain, Ankur Vaidya and Kuldeep Bansal
8. Caspase-9 gene mutation and its activators
Ravichandran Veerasamy
9. Caspases activity assay procedures
Sourabh Satapathy, Shivam Kumar, Vaibhav Nigam, Balak Das Kurmi, Ankur Vaidya, Akash Ved and Preeti Patel
10. Current and future prospective of caspases targeting in cancer therapy
Disha Prabhu, Surendra Jain, Rakesh Chawala, Shweta Jain and Ankur Vaidya
About the author
Dr. Ankur Vaidya obtained his PhD from Dr. H.S. Gour University, when he researched design, synthesis, and screening of a few quinoline and oxadiazole derivatives for anticancer activities. He has 12 years of experience in teaching and research, and already supervised 18 PhD students. He wrote 5 book chapters and co-authored 2 books, including Nanotechnology Applications for Cancer Chemotherapy (Elsevier, 2020).
