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The diagnostic application of MRI Contrast agents, both in the form of Gd3+ and transition metal complexes, like Mn at different oxidation states, as well as of nanomaterials, such as iron oxides, ferrites and Ln3+ salts, including their theranostic potential, is described in detail.
List of contents
Chapter 1 Synthesis and Characterization of Ligands and Their Gd(III) Complexes
Raphaël Tripier, Maryline Beyler
Chapter 2 PARASHIFT Systems: Including 19F Effects
Peter Harvey
Chapter 3 Targeted MRI Contrast Agents
Alexander G. Sertage, Md. Sydul Islam, and Matthew J. Allen
Chapter 4 Responsive MRI Contrast Agents
Luke A. Marchetti, Manon Isaac, Célia S. Bonnet
Chapter 5 Mn-Based Small Complexes as MRI Contrast Agents
Zoltán Garda, Sara Lacerda and Éva Tóth
Chapter 6 Other First-Row Transition Metal-Based Complexes as MRI Contrast Agents
Janet R. Morrow and Jaclyn J. Raymond
Chapter 7 Lanthanide-based paramagnetic chemical exchange saturation transfer (paraCEST) agents for MRI
A. Dean Sherry & Mark Woods
Chapter 8 LipoCEST and Similar Systems
Silvio Aime and Enzo Terreno
Chapter 9 Superparamagnetic Iron Oxide and Ferrite Nanoparticles for MRI
Thomas Vangijzegem, Levy Van Leuven, Dimitri Stanicki, Robert N. Muller, Sophie Laurent
Chapter 10 Ln-based particles as MRI contrast agents
Joop A. Peters and Kristina Djanashvili
Chapter 11 Manganese and Iron Based Nanoparticles as MRI Contrast Agents
Fabio Carniato, Lorenzo Tei, and Carlos F,G. C. Geraldes
Chapter 12 Advances in PET/MRI and Probe Development for Biomedical Precision Imaging Applications
Jan Kretschmer, Juan Pellico, Angelina Prytula-Kurkunova, Rafael Torres Martin De Rosales, Andre Ferreira Martins
About the author
Carlos F. G. C. Geraldes received his “Licenciatura” (MS equivalent) in Chemistry from the University of Coimbra in 1972, and his Doctor of Philosophy (D.Phil) degree in Inorganic Chemistry from the University of Oxford in 1976 with Prof. Robert J. P. Williams. In his graduate work, he studied the solution conformation of a series of mono and dinucleotides using the so-called Lanthanide Probe Method, measuring the proton NMR induced shifts and nuclear relaxation rates of their complexes of whole paramagnetic Ln(III) series combined with coupling constants and NOE data.
Summary
The diagnostic application of MRI Contrast agents, both in the form of Gd3+ and transition metal complexes, like Mn at different oxidation states, as well as of nanomaterials, such as iron oxides, ferrites and Ln3+ salts, including their theranostic potential, is described in detail.
