Ion channels of exitable membranes - 3rd ed

Zusatztext The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe." Informationen zum Autor Bertil Hille is Professor in the Department of Physiology and Biophysics at the University of Washington. He graduated summa cum laude from Yale University with a B.S. in Zoology, and earned a Ph.D. in Life Sciences at The Rockefeller University. Dr. Hille then did postdoctoral work in the laboratories of A. L. Hodgkin and R. D. Keynes. He was elected to the National Academy of Sciences in 1986, and has received numerous awards, including: the Third Annual Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1990); the Columbia University Louisa Gross Horwitz Prize for Biology or Biochemistry (1996, shared with Clay Armstrong); and the Albert Lasker Basic Medical Research Award (1999, jointly with Clay Armstrong and Roderick MacKinnon). A cell physiologist, neurobiologist, and educator, Dr. Hille works on ion channel biophysics, signaling by modulatory neurotransmitters, and intracellular calcium dynamics. Klappentext This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. Ionic Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognised authoritative overview of this field used by all neuroscientists. Zusammenfassung This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. Inhaltsverzeichnis 1. Introduction PART I: Description of Channels 2. Classical Biophysics of the Squid Giant Axon 3. The Superfamily of Voltage-Gated Channels 4. Voltage-Gated Calcium Channels 5. Potassium Channels and Chloride Channels 6. Ligand-Gated Channels of Fast Chemical Synapses 7. Modulation, Slow Synaptic Action, and Second Messengers 8. Sensory Transduction and Excitable Cells 9. Calcium Dynamics, Epithelial Transport, and Intercellular Coupling PART II: Principles and Mechanisms of Functions 10. Elementary Properties of Ions in Solution 11. Elementary Properties of Pores 12. Counting Channels and Measuring Fluctuations 13. Structure of Channel Proteins 14. Selective Permeability: Independence 15. Selective Permeability: Saturation and Binding 16. Classical Mechanisms of Block 17. Structure-Function Studies of Permeation and Block 18. Gating Mechanisms: Kinetic Thinking 19. Gating: Voltage Sensing and Inactivation

List of contents

• 1. Introduction


• PART I: Description of Channels


• 2. Classical Biophysics of the Squid Giant Axon


• 3. The Superfamily of Voltage-Gated Channels


• 4. Voltage-Gated Calcium Channels


• 5. Potassium Channels and Chloride Channels


• 6. Ligand-Gated Channels of Fast Chemical Synapses


• 7. Modulation, Slow Synaptic Action, and Second Messengers


• 8. Sensory Transduction and Excitable Cells


• 9. Calcium Dynamics, Epithelial Transport, and Intercellular Coupling


• PART II: Principles and Mechanisms of Functions


• 10. Elementary Properties of Ions in Solution


• 11. Elementary Properties of Pores


• 12. Counting Channels and Measuring Fluctuations


• 13. Structure of Channel Proteins


• 14. Selective Permeability: Independence


• 15. Selective Permeability: Saturation and Binding


• 16. Classical Mechanisms of Block


• 17. Structure-Function Studies of Permeation and Block


• 18. Gating Mechanisms: Kinetic Thinking


• 19. Gating: Voltage Sensing and Inactivation


• 20. Modification of Gating in Voltage-Sensitive Channels


• 21. Cell Biology and Channels


• 22. Evolution and Origins

Report

The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe."
Steven A. N. Goldstein, Cell

Product details

• Authors: bertil Hill, Bertil Hille, Hille Bertil
• Publisher: External catalogues UK
• Languages: English
• Product format: Hardback
• Released: 15.08.2001
• EAN: 9780878933211
• ISBN: 978-0-87893-321-1
• Dimensions: 180 mm x 240 mm x 40 mm
• Subjects: Humanities, art, music > Psychology > General, dictionaries; Natural sciences, medicine, IT, technology > Biology > General, dictionaries; Evolution, MOLECULAR MECHANISMS, SCIENCE / Life Sciences / Cell Biology, Biology, molecular biology, cell, proteins, membrane, Cellular biology (cytology), Axon, Biophysics, Cell Biology, Structural Biology, Activation