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List of contents
Section I. Introduction to Mitochondrial Diseases 1. Mitochondrial disease in neurology - Past, present, and future
Section II. Most Common Neurological Manifestations of Mitochondrial Disease2. Progressive external ophthalmoplegia
3. Mitochondrial optic neuropathies
4. Leigh syndrome
5. Stroke-like episodes in adult mitochondrial disease
6. Ataxia and spastic paraplegia in mitochondrial disease
7. Peripheral neuropathy in mitochondrial disease
8. Complex neurological and multisystem presentations in mitochondrial disease
Section III. Diagnosing Mitochondrial Disease9. Investigation of oxidative phosphorylation activity and composition in mitochondrial disease
10. Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis
11. Laboratory and metabolic investigations
12. Neuroimaging in mitochondrial disease
Section IV. Therapy and Future Challenges13. Currently available therapies in mitochondrial disease
14. Reproductive options in mitochondrial disease
15. Clinical trials in mitochondrial disease
16. Blood biomarkers of mitochondrial disease - One for all or all for one?
17. Experimental therapy for mitochondrial diseases
About the author
Rita Horvath works in the Department of Clinical Neurosciences at the University of Cambridge, John van Geest Centre for Brain Repair, Cambridge, United KingdomMichio Hirano is the Lucy G. Moses Professor, Director of the H. Houston Merritt Neuromuscular Research Center, and Chief of the Division of Neuromuscular Medicine in the Department of Neurology at the Columbia University Irving Medical Center, New York, NY, United States.Patrick Francis Chinnery works at the MRC Mitochondrial Biology Unit and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
