Inhalation Studies - Foundations and Techniques

Informationen zum Autor ROBERT PHALEN Ph.D., co-directs the Air Pollution Health Effects Laboratory at the University of California, Irvine (UCI). He also holds two academic appointments in the College of Health Sciences at UCI: Professor in the Department of Community and Environmental Medicine; and Professor in the Department of Medicine’s Center for Occupational and Environmental Health. He has served as Chair of both the UCI Institutional Review Board (for Human Studies) and the Institutional Animal Care and Use Committee. He is currently a member of the United States Environmental Protection Agency’s Clean Air Scientific Advisory Committee—Particulate Material, and he is a member of 11 professional scientific associations/societies. In 1971, he obtained a Ph.D. in biophysics, with specialization in inhalation toxicology, from the University of Rochester (in Rochester, NY). His postdoctoral research was conducted at the Inhalation Toxicology Research Institute (now the Lovelace Respiratory Research Institute) in Albuquerque, NM. In 1972, Dr. Phalen joined the then College of Medicine at UCI to establish the Air Pollution Health Effects Laboratory, which still conducts studies relating to the toxicology of air pollutants, and trains graduate students and physicians in inhalation toxicology. His research is in several areas including: predicting doses from inhaled particles; health effects of inhaled air pollutants; and applied aerosol physics. He has published over 100 scientific papers, and authored and/or edited four previous books on aerosol inhalation topics. Klappentext This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution.The Second Edition was motivated by:new developments in the ultrafine particle health effects and concentrated aerosol researchadvances in understanding postnatal lung growth and the deposition and clearance of inhaled particlesnew techniques in toxicity testingthe explosion of knowledge in the genetic and molecular realmsthe introduction of a large number of transgenic animal modelsupdated ethical guidelines for animal testingthe emergence of aerosol medicinethe growing threat of aerosol-related terrorismincreased appreciation of nonpulmonary effects of inhaled substancesuse of medical scanning techniques to study respiratory tract structurethe introduction of new inhalation exposure systemsthe emergence of aerosol concentrators for use in air pollution studies Zusammenfassung This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution. Inhaltsverzeichnis 1. Aerosols and Gases. Introduction. Direct Observation of Aerosol Particles. Cigarette Smoke: A Familiar Aerosol System. Particle Size. Size Distributions. Aerosol Properties. Aerosol Dynamics. Particle Size and Toxicity. Properties of Gases. 2.The Respiratory Tract. Introduction. Postnatal Development. Compartments. Gross Anatomy. Cells and Tissues. Ventilation. Deposition of Inhaled Particles. Uptake of Inhaled Gases. Defenses. 3. Establishing and Controlling Exposures. Introduction. Cleaning and Conditioning. Throughput Air. Aerosol Generation. Gas Generation. Mixed Aerosols and Gases. Principles for Stabilizing the Exposure Atmosphere. 4. Characterizing Exposures. Introduction. The Breathing Zone. What should be Measured? Instrumentation. Eliminating Measurement Interfe...

Product details

• Authors: Robert F Phalen, Robert F. Phalen, Robert F. (University of California At Irv Phalen, Phalen Robert F.
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 22.10.2008
• EAN: 9780849314001
• ISBN: 978-0-8493-1400-1
• No. of pages: 288
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; PHYSIOLOGY, MEDICAL / Physiology