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Informationen zum Autor Eddy Arnold and Daniel M. Himmel are the authors of International Tables for Crystallography, Volume F, 2nd Edition, Crystallography of Biological Macromolecules, published by Wiley. Klappentext International Tables for Crystallography Volume F is an expert guide to macromolecular crystallography for the structural biologist. It was commissioned by the International Union of Crystallography in recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell. The volume covers all stages of a crystallographic analysis from the preparation of recombinant proteins, through crystallization, diffraction data collection, phase determination, structure validation and structure analysis.Although the volume is written for experienced scientists, it is recognized that the reader is more likely to be a biologist interested in structure than a classical crystallographer interested in biology. Thus, there are chapters on the fundamentals, history and current perspectives of macromolecular crystallography, as well as on useful programs and databases such as the Protein Data Bank. Each chapter is written by one or more internationally recognized experts.This second edition features 19 new articles and many articles from the first edition have been revised. The new articles cover topics such as standard definitions for quality indicators, expression of membrane proteins, protein engineering, high-throughput crystallography, imaging of whole cells, radiation damage, merohedral twinning, low-resolution ab initio phasing, robotic crystal loading, whole-cell X-ray diffraction imaging and halogen interactions in biological crystal structures. There are also new articles on relevant software, including software for electron microscopy. These enhancements will ensure that Volume F continues to be a key reference for macromolecular crystallographers and structural biologists. Zusammenfassung This volume was commissioned by the International Union of Crystallography (IUCr) in recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell, and to the growing field of structural genomics. Inhaltsverzeichnis Preface (M.G. Rossmann and E. Arnold). PART 1 INTRODUCTION. 1.1 Overview (E. Arnold and M.G. Rossmann). 1.2 Historical Background (M.G. Rossmann). 1.3 Macromolecular Crystallography and Medicine (W.G.J. Hol and C.L.M.J.Verlinde). 1.4 Perspectives for the Future. PART 2 BASIC CRYSTALLOGRAPHY. 2.1 Introduction to Basic Crystallography (J. Drenth). PART 3 TECHNIQUES OF MOLECULAR BIOLOGY. 3.1 Preparing Recombinant Proteins for X-Ray Crystallography (S.H. Hughes and A.M. Stock). PART 4 CRYSTALLIZATION. 4.1 General Methods (R. Giegé and A. McPherson). 4.2 Crystallization of Membrane Proteins (H. Michel). 4.3 Application of Protein Engineering to Improve Crystal Properties (D.R. Davies and A. Burgess Hickman). PART 5 CRYSTAL PROPERTIES AND HANDLING. 5.1 Crystal Morphology, Optical Properties of Crystals and Crystal Mounting (H.L. Carrell and J.P. Glusker). 5.2 Crystal-Density Measurements (E.M. Westbrook). PART 6 RADIATION SOURCES AND OPTICS. 6.1 X-Ray Sources (U.W. Arndt). 6.2 Neutron Sources (B.P. Schoenborn and R. Knott). PART 7 X-RAY DETECTORS. 7.1 Comparison of X-Ray Detectors (S.M. Gruner, E.F. Eikenberry and M.W. Tate). 7.2 CCD Detectors (M.W. Tate, E.F. Eikenberry and S.M. Gruner). PART 8 SYNCHROTRON CRYSTALLOGRAPHY. 8.1 Synchrotron-Radiation Instrumentation, Methods and Scientific Utilization (J.R. Helliwell). 8.2 Laue Cr...
