Fr. 57.50

The immune microenvironment of bladder cancer

English · Paperback / Softback

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Description

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The analysis of tumor-infiltrating lymphocytes (TILs) is recognized as a prognostic factor in several cancers. The objective of our work was to study by immunohistochemical method the phenotype, density and distribution of TILs in urothelial carcinomas of the bladder and to analyze their prognostic impact. This was a retrospective descriptive study involving 35 samples of urothelial carcinomas of the bladder infiltrating at least the chorion, collected at the pathological anatomy department of the Marsa internal security forces hospital between 2010 and 2021. TILs were detected using anti-differentiation cluster antibodies CD3, CD8 and CD25, intra- and peri-tumoral. The cell count was carried out on 5 consecutive fields at high magnification. An Immunoscore as well as the CD25/CD3 ratio were calculated in each case. Densities and ratios were categorized into low and high based on the median. The correlation between: clinicopathological parameters and the density of TILs, Immunoscore, CD25/CD3 ratio was studied.

About the author










Dott.ssa Sarra Ben Rejeb, assistente ospedaliera universitaria.Capo del Dipartimento di Anatomia Patologica, Tunisia.

Product details

Authors Sarra Ben Rejeb, Nadia Kouki
Publisher Our Knowledge Publishing
 
Languages English
Product format Paperback / Softback
Released 11.12.2023
 
EAN 9786206922971
ISBN 9786206922971
No. of pages 88
Subject Natural sciences, medicine, IT, technology > Medicine > General

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