Hematopoietic Stem Cell Transplantation and Cellular Therapies for - Autoimmune Disease

Summary

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.
Key Features

• Outlines therapies and techniques for HSCT for autoimmune diseases


• Discusses the advantages of HSCT over conventional therapies


• Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Product details

• Authors: Richard K. (Northwestern University Burt
• Assisted by: Richard K. Burt (Editor), Burt Richard K. (Editor), Dominique Farge (Editor), Milton A. Ruiz (Editor), Riccardo Saccardi (Editor), John A. Snowden (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 18.11.2021
• EAN: 9781138558557
• ISBN: 978-1-138-55855-7
• No. of pages: 666
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Immunology, MEDICAL / General, MEDICAL / Immunology, MEDICAL / Clinical Medicine, MEDICAL / Rheumatology, MEDICAL / Hematology, Rheumatology, Other branches of medicine, Regenerative medicine: stem cells