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Informationen zum Autor Gary Evans Klappentext Taking a unique industrial perspective that reinforces theory and develops valuable analytical and interpretation skills, this book examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. Professionals with extensive experience in drug discovery and development, as well as specialized knowledge of the individual topics, contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics, and drug-drug interactions. Zusammenfassung An invaluable guide for pharmacology students and professionals which will help to reinforce the theory in the subject of drug metabolism, and help develop valuable analytical and interpreting skills. Inhaltsverzeichnis The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II Enzymes. In vitro Techniques for Investigating Metabolism. Drug-Drug Interactions: an in vitro Approach. Clinical Impact of Drug Interactions. Preclinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modeling in Preclinical Drug Discovery. Toxicokinetics. Protein Binding in Plasma: A Case History of a Highly Protein Bound Drug. Metabolite Identification by Spectroscopy. Whole Body Autoradiography. Radiolabeled Studies in Man. Molecular Biology.
