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Informationen zum Autor Prof. Ahindra Nag is a Professor in the Chemistry Department at IIT Kharagpur. He has more than 3 decades of teaching and research experience. He has published 8 textbooks! 80 research papers in renowned journals and have guided 10 research scholars. He has also been granted with 3 industrial patents. He was invited as a Visting Professor in Academia Sinica (Taiwan)! University of Molise ( Italy ) and Universty of Tennesse (USA). Klappentext This book focuses on different techniques of asymmetric synthesis of important compounds! such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic! Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds. Zusammenfassung This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. Inhaltsverzeichnis Chapter 1 Basic Stereochemical Approaches to Natural Products and Drugs. 1.1Basic concept of Chirality. 1.2 Meso compounds. 1.3 Tautomerism and Valance Tautomerism. 1.4 Conformation.Fischer Projection and Absolute Configuration. 1.5 Chiral Resolution. Application of Enantiomers in Drugs and Natural Products 1.7. References Problems and answers Chapter- 2: Diastereoselective Addition of Organometallic Reagents to Chiral Carbonyl Compounds 2.1. Introduction 2.2. Models for Asymmetric carbonyl compounds addition 2.3 Models for 1,3 Asymmetric carbonyl addition 2.4. Addition reactions of achiral reagent 2.5. Addition of aldehyde 2.6. Addition of Chiral ketones 2.7. Conclusion 2.8. References Chapter- 3: Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes 3.1.Introduction 3.2 History 3.3. Mechanism of Dirhodium(II) – catalysed cycloprpanation reactions 3.4.Electronic modifications4.1.2.Steric modifications 3.5.Dirhodium ( II) carboxylate complexes 3.6.Dirhodium(II) catalysts-derived from chiral N-protected amino acid ligands 3.7.Dirhodium(II) catalysts derived from substituted cyclopropane carboxylate ligands 3.8.Dirhodium (II) carboxamidates complexes 3.9.Effects of axial ligands on Enantioselectivity 3.10. Conclusion 3.11. References Chapter – 4: Chirality Organization of Peptide and -Conjugated Polyanilines 4.1. Introduction 4.2 Chirality Organization of Peptides 4.2.1 Chirality Organization of Peptides by Using Organic Molecular Scaffold 4.2.2 Chirality Organization of Peptides by Using Organometallic Molecular Scaffold 4.3 Synthesis of Optically Active Polyanilines 4.3.1 Polymerization of Anilines in the Presence of a Chiral Acid 4.3.2 Doping of Emeraldine Bases with a Chiral Acid 4.3.3 Introduction of Chiral Groups into Polyanilines 4.4 Chiral Complexation of Emeraldine Bases with Chiral Complexes 4.5 Application of Optically Active Polyanilines 4.6. Conclusion 4.7.Reference Chapter -5: Diastereoselective Syntheses of Iminosugars 5.0. Introduction 5.1. Syntheses from the Chiral Pool 5.2. Bio-catalyzed syntheses. 5.3. Asymmetric Syntheses 5.4. Conclusion and Future Directions 5.5. References Chaptere-6: The use of specific new artificial or semisynthetic bio-catalysts for synthesis of regio- and enantioselective compounds 6.1. Introduction 6.2. Regioselective preparation of monodeprotected esters 6.3. Refrences Chapter – 7: Bioactive Natural Products and Their Structure-Activity Relationships Studies 7.1 Introduction 7.2 Anti-Microbial Natural Produ...
