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Featuring contributions from renowned subject-matter experts, this book provides a better understanding of how inhaled nanoparticles behave in the lungs and body. It describes the sequence of events that nanoparticles encounter in the lungs when moving from the air into the bloodstream, as well as addresses practical considerations for drug delivery to the respiratory tract, drug and gene delivery in the lungs, and bio-nanocapsules. In addition, the book explores issues such as dosimetry for
in vitro nanotoxicology and the potential for nose-to-brain delivery of drugs.
List of contents
Introduction. Deposition. Interaction with the Lung Surface. Role of the Biomolecule Corona in Nanoparticle Fate and Behavior. Interaction with Alveolar Lining Fluid. Interaction with Lung Macrophages. Interactions with Alveolar Epithelium. Mechanistic Aspects of Cellular Uptake. Cellular Uptake and Intracellular Trafficking.
Translocation across the Air-Blood Tissue Barrier. The Pulmonary Lymphatic System. Translocation and Accumulation in the Body. Practical Considerations for Drug Delivery to the Respiratory Tract. Drug and Gene Delivery in the Lungs. Bio-Nanocapsules: Novel Drug Delivery. Physicochemical, Colloidal, and Transport Properties. Dosimetry for
In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore. Potential for Nose-to-Brain Delivery of Drugs. The Developing Lungs. Nanotoxicology. Summary.
About the author
Akira Tsuda is a principal research scientist in the Molecular and Integrative Physiological Sciences Program at the Harvard School of Public Health. He is the author of more than 100 peer-reviewed articles and mentor of postdoctors (Harvard School of Public Health and Harvard Medical School). He serves as a reviewer for many international scientific journals, as well as research grants. He was a member of the NIH Respiratory Physiology, Respiratory Integrative Biology, and Translational Research Study Section, and is currently on the editorial board of the Journal of Applied Physiology and Journal of Aerosol Medicine and Pulmonary Drug Delivery.
Peter Gehr is a professor emeritus at the University of Bern. Previously, he was chair of the Institute of Anatomy. He has served as visiting assistant professor at the Harvard School of Public Health and guest professor at the University of Nairobi. He spent sabbaticals at the University of Western Australia, National Jewish Health in Denver, and Harvard School of Public Health. He is currently the president of the Steering Committee of the National Research Program on Opportunities and Risks of Nanomaterials of the Swiss National Science Foundation, and a member of the Swiss Federal Commission for Air Hygiene.
