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Informationen zum Autor Kamel Khalili , PhD, Professor and Chair, Department of Neuroscience, Temple University, and Kuan-Teh Jeang , MD, PhD, Head, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, NIH, are among the leading scientists in the field of human DNA and RNA viruses. Each of them has more than 25 years' experience in studying oncogenic viruses. Klappentext Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi's associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments. Zusammenfassung Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. Inhaltsverzeichnis Foreword vii Preface xi Contributors xiii 1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1 Rachel A. Katzenellenbogen and Denise A. Galloway 2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23 Amy Baldwin and Karl Münger 3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57 Miranda Thomas, David Pim, and Lawrence Banks 4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89 Krzysztof Reiss, Kamel Khalili, and Luis Del Valle 5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113 C. Richard Boland, Luigi Ricciardiello, and Ajay Goel 6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129 Michael J. Imperiale and Dweepanita Das 7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149 Abhilasha V. Rathi and James M. Pipas 8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165 Janet S. Butel 9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191 Natalya Baranova and Michele Carbone 10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211 Timothy M. Block and Anand S. Mehta 11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225 Mei-Hwei Chang and Ding-Shinn Chen 12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243 Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun 13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267 Donna Sir and Jing-Hsiung James Ou 14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279 Masao Matsuoka 15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295 Susan J. Marriott 16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317 Melissa Agsalda and Bruce Shiramizu 17 HIV-RELATED LYMPHOMA 337 Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini 18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351 Veenu Minhas and Charles Wood 19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI'S SARCOMA 377 Gary S. Ha...
