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The mechanics underlying the form and structure of biological tissues is being increasingly investigated and appreciated, with new results appearing at a fast pace. Cellular Patterns covers the salient elements of this thriving field of research in a textbook style, including both historic landmark results and recent achievements.
By building on concepts such as packing, confinement, surface tension, and elastic instabilities, the book explains the structure and the shape of sheet-like and bulk tissues by adapting the mechanics of continuous media to living matter. It reviews experimental results and empirical laws, and wherever possible, it discusses more than a single theoretical interpretation of a given phenomenon.
The in-depth treatment of technical details, the many boxes summarizing essential physical and biological ideas, and an extensive set of problems make this book suitable as a complementary textbook for a graduate course in biophysics and as a standalone reference for students and researchers in biophysics, bioengineering, and mathematical biology interested in the mechanics of tissue.
Features:
Provides an overview of patterns and shapes seen in animal tissues in addition to an interpretation of these structures in terms of physical forces and processes
Contains detailed analysis and a critical comparison of mechanical models of cells, tissues, and morphogenetic movements
Presents a visually rich style which is accessible to physicists and biologists alike
List of contents
Introduction. Cells as physical objects. Inplane structure of singlelayer tissues. Shape of epithelia. Morphogenesis. Bulk tissues. Afterthoughts.
About the author
Antonio Siber, Institute of Physics, Zagreb, Croatia
Primoz Ziherl, Faculty of Mathematics and Physics, University of Ljubljana, and Jozef Stefan Institute, Ljubljana, Slovenia
Summary
This book explores biological tissue patterns, such as the checkerboard pattern of light and dark cells in the Japanese quail oviduct, and interprets these patterns using models based, for example, on the forces that make raindrops spherical, enabling readers to understand why these patterns appear.
