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A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy
List of contents
Chapter 1. Background
Chapter 2. Introduction to Vaccination
Chapter 3. Fundamentals of Modern Peptide Synthesis
Chapter 4. Peptide Synthesis and Characterization Stages
Chapter 5. Conjugation of Polymers with Biomolecules and Polymeric Vaccine Development Technologies
Chapter 6. What are Polymeric Carriers?
Chapter 7. Conjugation and Other Methods in Polymeric Vaccines
Chapter 8. Polymeric Nanoparticle Preparation Methods
Chapter 9. Peptides in Brain Disorders
Chapter 10. Pseudo-proteins and related synthetic amino acid based polymers promising for constructing artificial vaccines
Chapter 11. Peptide Vaccines in Cancer Diseases
Chapter 12. Antioxidant Peptides
Chapter 13. Peptide Vaccine
Chapter 14. Adjuvants Of Vaccine in Immunotoxicology
Chapter 15. Role of Epigenetics in Immunity and Immune Response to Vaccination
Chapter 16. "Omics" technologies in vaccine research
Chapter 17. Computer-Aided Epitope Identification and Design of Epitope Mimetics.
About the author
Assoc. Prof. Dr. Mesut Karahan graduated from Yildiz Technical University, Faculty of Arts and Sciences Department of Chemistry in 1999. Between 2001 and 2012, Dr. Karahan worked in Yildiz Technical University. He got his master’s degree in 2002 at the same university with his study titled "Ternary Polymer-Metal-Protein Complex Structure Models". Assoc. Prof. Dr. Karahan completed his Ph.D. studies in 2009 on "Development of Functional Biopolymer Systems Containing Metal”. He has been working at Üsküdar University since 2012. Working Areas: Vaccine Systems, Diagnostic Kit, Biochemistry, Biopolymer Systems, Peptide Synthesis, Proteins, Bioconjugation, Biopolymer-Metal-Peptide Complexes.
Summary
A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes – the future of vaccination. The book illustrates the use of peptides vaccine systems and makes predictions of future development.
