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Informationen zum Autor Raimo Pohjanvirta, PhD, is Professor of Toxicology at the University of Helsinki. He has been studying the effects and action mechanisms of dioxins for over twenty years, publishing over a hundred peer-reviewed papers on dioxins and AHR. Dr. Pohjanvirta has been an invited lecturer at major international conferences, including the Society of Toxicology, EUROTOX, and the British Toxicology Society. Klappentext The complete guide to the aryl hydrocarbon receptor (AHR)-what it is, what it does, and what it might mean for the future of drug metabolismProviding a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the induction of drug-metabolizing enzymes and diverse toxicities caused by dioxins, The AH Receptor in Biology and Toxicology is essential reading for toxicologists, chemists, biologists, pharmacologists, and other experts studying drug metabolism.Evidence suggests that the AHR protein imparts important physiological functions that place it at the crossroad of biology and toxicology, making it the focus of extensive research activity. Examining the unique dual role of AHR as both a toxicant and a factor in biological processes, this comprehensive reference work covers the full spectrum of AHR topics from basic concepts, toxicological risk analysis, and models, to polymorphisms and related diseases. Addressing epigenetic mechanisms, gene expression, reproductive/developmental toxicity, signal transduction, and transgenic animal models, the book runs the gamut of AHR knowledge.With contributions from renowned international experts, The AH Receptor in Biology and Toxicology puts the forefront of AHR research at your fingertips. Zusammenfassung This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Inhaltsverzeichnis Preface. A. Historical background. 1. History of Research on the AHR ( Thomas A. Gasiewocz and Ellen C. Henry ). B. AHR as a ligand-activated transcription factor. 2. Overview of AHR functional domains and the classical signaling pathway: induction of drug-metabolizing enzymes ( Qiang Ma ). 3. Role of chaperone proteins in AHR function ( Iain A. Murray and Gary H. Perdew ). 4. AHR Ligands: Promiscuity in Binding and Diversity in Response ( Danica DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandin and Michael S. Denison ). 5. Dioxin response elements and regulation of gene transcription ( Hollie Swanson ). 6. The AHR/ARNT dimer and transcriptional coactivators ( Oliver Hankinson ). 7. Regulation of AHR by the AHR repressor (AHRR) ( Yoshiaki Fujii-Kuriyama and Kaname Kawajiri ). 8. Influence of HIF-1¿ and Nrf2 signaling on AHR-mediated gene expression, toxicity and biological functions ( Thomas Haarmann-Stemmann and Josef Abel ). 9. Functional interactions of AHR with other receptors ( Sara Brunnberg, Elin Swedenborg and Jan-Åke Gustafsson ). 10. The E3 ubiquitin ligase activity of transcription factor AHR permits non-genomic regulation of biological pathways ( Fumiaki Ohtake and Shigeaki Kato ). 11. Epigenetic mechanisms in AHR function ( Chia-I Ko and Alvaro Puga ). C. AHR as a mediator of xenobiotic toxicities: dioxins as a key example. 12. Role of the AHR and its structure in TCDD toxicity ( Raimo Pohjanvirta, Merja Korkalainen, Ivy D. Moffat, Paul C. Boutros, Allan B. Okey ). 13. Nongenomic route of action of TCDD: Identity, characteristics and toxicological significance ( Fumio Matsumura ). 14. Int...
