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Informationen zum Autor Dr. Stefan Faderl specializes in acute and chronic leukemias. His main areas of interest include acute lymphoblastic leukemias (ALL), acute myeloid leukemias (AML), chronic lymphocytic leukemia (CLL) and its variants, as well as chronic myeloid leukemias (CML). Dr. Hagop M. Kantarjian is Professor of Medicine and Chairman of the Department of Leukemia at MD Anderson Cancer Center in Houston, Texas. He specializes in leukemia and is interested in creating new treatment approaches for these diseases. He has authored and contributed to over 560 medical publications, articles, and abstracts. Klappentext Edited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area Zusammenfassung Edited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Inhaltsverzeichnis Contributors. Preface. Part 1: Background and Diagnostic. 1. Stem Cell Biology in Normal and Malignant Hematopoiesis ( Amer Zeidan and Meir Wetzler ). 2. Epidemiology and Etiology of Leukemias ( Andrew Fletcher, Annika Whittle and David Bowen ). 3. Traditional Diagnostic Approaches ( Hartmut Koeppen, Carlos E. Bueso-Ramos and Sergej N. Konoplev ). 4. Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification ( Maher Albitar ). 5. Non-cytogenetic Markers and Their Impact on Prognosis ( Eric Schafer and Donald Small ). Part 2: Myelodysplastic syndromes (MDS). 6. Myelodysplastic Syndromes: Pathophysiology ( Steven D. Gore and Erica Warlick ). 7. Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment ( Ulrich Germing ). 8. Myelodysplastic Syndromes ( William Stevenson and Guillermo Garcia-Manero ). Part 3: Acute Myeloid Leukemia (AML). 9. Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia ( Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, and Ulrike Bacher ). 10. Induction Therapy of Acute Myeloid Leukemia ( Martha Wadleigh and Daniel J. DeAngelo ). 11. Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies ( Keith W. Pratz and Judith E. Karp ). 12. Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia ( Gheath Alatrash and Marcos de Lima ). Part 4: Acute Promyelocytic Leukemia (APL). 13. The Pathophysiology of Acute Promyelocytic Leukemia ( Francesco Lo-Coco and Syed Khizer H...
