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Informationen zum Autor ANKE-HILSE MAITLAND-VAN DER ZEE, PHD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands. ANN K. DALY, PHD, is Professor of Pharmacogenetics at Newcastle University, UK. Klappentext The one-stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practicesPharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level-and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics.The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.Including chapters on specific therapeutic areas and clinical aspects, Pharmacogenetics and Individualized Therapy helps readers, whether they're students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics. Zusammenfassung This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. Inhaltsverzeichnis Preface vii Contributors ix 1. Pharmacogenetics: A Historical Perspective 1 Ann K. Daly Part I Pharmacogenetics: Relationship to Pharmacokinetics and Pharmacodynamics 2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15 Vita Dol ?an 3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81 Ingolf Cascorbi 4. Pharmacogenetics of Drug Transporters 101 Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer 5. Pharmacogenetics of Drug Targets 149 Ann K. Daly and Maria Arranz Part II Pharmacogenetics: Therapeutic Areas 6. Cardiovascular Pharmacogenetics 185 Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke-Hilse Maitland-van der Zee 7. Pharmacogenetics in Psychiatry 215 Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K. Daly 8. Pharmacogenetics in Cancer 251 Sharon Marsh 9. Pharmacogenetics of Asthma and COPD 271 Ellen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and Gerard H. Koppelman 10. Pharmacogenetics of Adverse Drug Reactions 295 Ann K. Daly, Martin Armstrong, and Munir Pirmohamed 11. Pharmacogenomics of Inflammatory Bowel Diseases 323 Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab 12. Pharmacogenetics of Pain Medication 353 J örn L ötsch Part III Pharmacogenetics: Implementation in Clinical Practice 13. Ethical and Social Issues in Pharmacogenomics Testing 377 Susanne Vijverberg, Toine Pieters, and Martina Cornel Part IV Developments in Pharmacogenetic Research 14. High-Throughput Genotyping Technologies for Pharmacogenetics 403 Beatriz Sob...
