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Informationen zum Autor BRAD BOLON, DVM, MS, PhD, Diplomate ACVP, Diplomate ABT, Fellow ATS, Fellow IATP , has spent over twenty years as a practitioner and teacher of toxicologic neuropathology. He is the founder of GEMpath, Inc., an experimental pathology consultancy specializing in drug discovery research. MARK T. BUTT, DVM, Diplomate ACVP, is the founder of Tox Path Specialists, LLC, a company that provides neuropathology and histology support to pharmaceutical and biotechnology firms developing novel therapies that target nervous system diseases. He has over twenty years' experience providing neuropathology support and has evaluated over four hundred studies supporting regulatory submissions for neuroactive compounds. Klappentext Grasp the fundamentals behind neuropathology Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques provides an introduction to the discipline and techniques of neuropathology. Aimed not only at pathologists and toxicologists, but more broadly at comparative neurotoxicologists, environmental scientists, students, and other experts working in the scientific and medical worlds as well, the book is an invaluable guide to understanding diseases of the central and peripheral nervous systems. With a focus on the practical applications of assessing chemical toxicity, the book addresses both the fundamentals of neuropathology, and provides detailed coverage of current practices in anatomic, biochemical, clinical, and molecular analyses. In addition, it examines the practical aspects of neuropathology, such as study design data interpretation, regulatory considerations, and tips for preparing reports. Describing the intricacies of the nervous system and the standard testing procedures that help toxicologists make neuropathological evaluations, Fundamental Neuropathology for Pathologists and Toxicologists is essential reading for anyone interested in understanding the chemical, environmental, biological, medical, and regulatory details important for analyzing toxicant-induced neurodiseases. Zusammenfassung Exposure to xenobiotics that can adversely impact the nervous system is a major concern in modern industrial society. Fundamental Neuropathology for Toxicologists introduces toxicologists to the discipline and techniques of neuropathology, including chemical and environmental, biological, medical, and regulatory details. Inhaltsverzeichnis Editors' Preface. Forward. Acknowledgments. Part I. Fundamentals of Neurobiology. Chapter 1. Fundamentals of Toxicologic Neuropathology: An Introduction. Chapter 2. Functional Neuroanatomy. Chapter 3. Atlas of Comparative Neuroanatomy. Chapter 4. Principles of Comparative and Correlative Neurodevelopment, and their Implications for Developmental Neurotoxicity. Chapter 5. Localizing Neuropathologic Lesions Using Neurologic Findings. Chapter 6. Behavioral Model Systems for Evaluating Neuropathology. Chapter 7. Cognitive Assessments in Non-Human Primates. Chapter 8. The Impact of Aging on Brain Structure and Function in Rodents and Canines. Chapter 9. Fundamentals of Neurotoxicity Detection. Part 2. Toxicologic Neuropathology: Methodology. Chapter 10. Practical Neuropathology of the Rat and Other Species. Chapter 11. The Fluoro-Jade Dyes: Novel, Sensitive, and Reliable Fluorochromes for the Histochemical Localization of Degenerating Neurons. Chapter 12. Histologic Markers of Neurotoxicity (Nonfluorenscence). Chapter 13. Common Histologic Artifacts in Nervous System Tissues. Chapter 14. High-Definition Microscopic Analysis of the Nervous System. Chapter 15. Stereological Solutions for Common Quantitative Endpoints in Neurotoxicity. Chapter 16. Anatomy and Processing of Peripheral Nerve Tissues. Chapter 17. Patho...
