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Informationen zum Autor ZHIQIANG AN, PHD, is the Chief Scientific Officer of Epitomics, Inc., in Burlingame, California. Previously, he was Director of Biologics Research at Merck Research Laboratories, West Point, Pennsylvania. Dr. An started his biotech/pharmaceutical career at Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts. He received a doctor of philosophy degree from the University of Kentucky, Lexington, followed by postdoctoral training at the University of Wisconsin?Madison. Klappentext * 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.* First book to address the discovery and development of antibody therapeutics in their entirety.* Most chapters contain experimental data to illustrate the principles described in them.* Authors provide detailed methodologies that readers can take away with them and use in their own laboratories Zusammenfassung 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Inhaltsverzeichnis Foreword ix Preface xi Contributors xiii Part I Antibody Basics 1. Therapeutic Monoclonal Antibodies: Past, Present, and Future 3 William R. Strohl 2. Antibody Molecular Structure 51 Robyn L. Stanfield and Ian A. Wilson 3. Glycosylation of Therapeutic IgGs 67 Yusuke Mimura, Roy Jefferis, Yuka Mimura-Kimura, Jodie Abrahams, and Pauline M. Rudd 4. Antibody Databases and Tools: The IMGTw Experience 91 Marie-Paule Lefranc Part II Antibody Sources 5. Human Antibodies from Transgenic Mice 117 Nils Lonberg 6. Rabbit Hybridoma 151 Weimin Zhu and Guo-Liang Yu 7. Human Antibody Repertoire Libraries 169 David Lowe and Tristan J. Vaughan Part III In Vitro Display Technology 8. Antibody Phage Display 191 Michael Hust, Holger Thie, Thomas Schirrmann, and Stefan D übel 9. Yeast Surface Display 213 Jennifer L. Lahti and Jennifer R. Cochran 10. Ribosomal Display 239 George Thom 11. Bacterial Display of Antibodies 255 Thomas J. Van Blarcom and Barrett R. Harvey 12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells 283 Ernest S. Smith and Maurice Zauderer Part IV Antibody Engineering 13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques 311 Juan C. Almagro and William R. Strohl 14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor 335 William F. Dall'Acqua and Herren Wu 15. Engineering the Antibody Fc Region for Optimal Effector Function 349 Greg A. Lazar and John R. Desjarlais Part V Physiology And In Vivo Biology 16. Antibody-Complement Interaction 373 Kileen L. Mershon and Sherie L. Morrison 17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications 385 Leslie Cope and Tessie McNeely 18. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies 417 Si-Han Hai, Julie A. McMurry, Paul M. Knopf, William Martin, and Anne S. De Groot 19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics 439 Christopher R. Gibson, Punam Sandhu, and William D. Hanley 20. Biodistribution and Imaging 461 Tove Olafsen and Anna M. W...
