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Zusatztext "?This is a unique book that offers information about what is currently known about the structure-function relationship of the complement system components. For researchers with an interest in this particular area! it would be an excellent source of information."-Doody's Review Services Informationen zum Autor Morikis\! Dimitrios; Lambris\! John D. Klappentext The only in-depth guide on the subject! this is the first resource to present the structural biology of the complement system in connection to immunology and drug development. Integrating the latest breakthroughs in structural biology and immunology! this book includes detailed discussions of the structure-function relationships among complement system components! regulators! receptors! and selected proteins and inhibitor. It also provides an introduction to the structural bioinformatics classification of complement proteins. The book comes with a CD containing color figures! a molecular structure visualization program! and files with three-dimensional coordinates of the structures. OTI #1: 3150 Zusammenfassung The only in-depth guide on the subject, this is the first resource to present the structural biology of the complement system in connection to immunology and drug development. Integrating the latest breakthroughs in structural biology and immunology, this book includes detailed discussions of the structure-function relationships among complement sy Inhaltsverzeichnis The Building Blocks of the Complement System. Complement Control Protein Modules in Regulators of Complement Activation. The Classical Pathway to C1 Complex. Factors D and B: Substrate-Inducible Serine Proteases of the Alternative Pathway of Complement Activation. The Structures of Human Complement Fragments C3d and C4Ad and the Functional Insights that They Have Provided. Complement Receptor CR2/CD21 and CR2-C3d Complexes. Structure of the Anaphylatoxins C3a and C5a. C3b/C4b Binding Site of Complement Receptor Type 1 (CR1, CD35). From Structure to Function of a Complement Regulator: Decay-Accelerating Factor (CD55). Complement Protein C8. Structure-Function Relationships in CD59. Complement-Like Repeats in Proteins of the Complement System. Complement and Immunoglobulin Protein Structures by X-Ray and Neutron Solution Scattering and Analytical Ultracentrifugation. Structure, Dynamics, Activity, and Function of Compstatin and Design of More Potent Analogues. Discovery of Potent Cyclic Antagonists of Human C5a Receptors. Index....
