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Informationen zum Autor Koji Kawakami, Bharat B. Aggarwal, Raj K. Puri Klappentext With the advent of advances in cytotoxins and immunotoxins! the promise of 'smart bomb' cancer therapies has been dawning for some time. Now! the first of these drugs has been approved by the FDA! and it is hoped that this will accelerate our understanding of cancer and lead to further treatments with the same approach. In this state of the art book! the editors bring together leading researchers to discuss clinical trial data concerning some of the most widely studied tumors. Researchers in cancer therapy! oncologists and immunologists have! in this single resource! access to important data and far-sighted thinking. Zusammenfassung This book discusses clinical trial data concerning some of the most widely studied tumours. 'Smart bomb' cancer treatments are also covered. Inhaltsverzeichnis Preface: An Overview of Immunotoxins and Cytotoxins in Clinical Trials. PART 1. PSEUDOMONAS EXOTOXIN (PE)-BASED IMMUNOTOXINS/CYTOTOXINS. Targeting of Pseudomonas Exotoxin-based Immunotoxins to Hematologic Malignancies. Interleukin-4-targeted Cytotoxin for Recurrent Glioblastoma Therapy. Interleukin-13 Receptors and Development of IL-13-Pseudomonas Exotoxin for Human Cancer Therapy. PART 2. RICIN-BASED IMMUNOTOXINS/CYTOTOXINS. Ricin Immunotoxins in Lymphomas. PART 3. DIPHTHERIA TOXIN (DT)-BASED IMMUNOTOXINS/CYTOTOXINS. Diphtheria-based Immunotoxins: Targeting Overexpressed Interleukin-13 Receptor and Urokinase-type Plasminogen Activator Receptor on Glioblastoma Multiforme. DAB389IL-2 (Ontak): Development and Therapeutic Applications. Transferrin Diphtheria Toxin for Brain Tumor Therapy. GM-CSF Receptor Targeted Therapy of Human Leukemia. VEGF-diphtheria toxin for Targeting of Tumor Blood Vessels. PART 4. MISCELLANEOUS. cBR-96-doxorubicin (SGN-15) for Metastatic Breast Cancer Therapy. Anti-CD33 Calicheamicin Immunoconjugate Therapy of Acute Myeloid Leukemia....
