Statistical Genetics - Gene Mapping Through Linkage and Association

Zusatztext "?well organized and is written and edited by enthusiastic experts. This will be a great starting place for anyone who wants to understand and! hopefully! get involved with research on the genetics of human complex traits." Twin Research and Human Genetics Informationen zum Autor Neale, Benjamin; Ferreira, Manuel ; Medland, Sarah; Posthuma, Danielle Klappentext Statistical Genetics focuses on conducting genetic linkage and association analysis in the post-genomic era. It covers established and new methodologies, providing the genetic and statistical theory on which they are based. Worked examples of important methods are given, as well as study design and sources of error. Zusammenfassung Statistical Genetics focuses on conducting genetic linkage and association analysis in the post-genomic era. It covers established and new methodologies, providing the genetic and statistical theory on which they are based. Worked examples of important methods are given, as well as study design and sources of error. Inhaltsverzeichnis 1. Introduction  2. DNA  3. Introduction to Biometrical Genetics  4. Introduction to Statistics  5. Statistical Power  6. Population Genetics and its Relevance to Gene Mapping  7. Principles of Linkage Analysis  8. IBD Estimation  9. Regression Methods for Linkage Analysis  10. Variance Components Linkage Analysis for Quantitative Traits  11. Extensions to Univariate Linkage Analysis  12. QTL Detection in Multivariate Data from Sibling Pairs  13. Factors Affecting Type I Error and Power of Linkage Analysis  14. Introduction to Association  15. Single-locus Association Models  16. Genome-wide Association  17. Haplotype Estimation  18. Multi-locus Association Models  19. Linkage Disequilibrium and Tagging  20. Haploview  21. Factors Affecting Type I Error and Power in Association  22. Resampling Approaches to Statistical Interference

Product details

• Authors: Benjamin (Center for Human Genetic Research Neale, Benjamin Ferreira Neale
• Assisted by: Manuel Ferreira (Editor), Ferreira Manuel (Editor), Sarah Medland (Editor), Medland Sarah (Editor), Benjamin Neale (Editor), Danielle Posthuma (Editor), Posthuma Danielle (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Paperback / Softback
• Released: 06.12.2007
• EAN: 9780415410403
• ISBN: 978-0-415-41040-3
• No. of pages: 606
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Epidemiology & medical statistics, SCIENCE / Life Sciences / General, SCIENCE / Life Sciences / Molecular Biology, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Life Sciences / Genetics & Genomics, Cellular biology (cytology), Genetics (non-medical), Epidemiology and Medical statistics