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Informationen zum Autor Barbara Migeon, MD, has held fellowships in pediatrics, endocrinology and genetics. She is board certified in pediatrics, biochemical genetics and cytogenetics. She was the founding director of the Hopkins PhD Program in Human Genetics. Her research has been focused on the molecular mechanisms of X inactivation in human cell and the clinical consequences of the single active X chromosome. Klappentext This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first edition. "This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine"Migeons eyewitness account of the discovery of X inactivation and the investigations of its mechanism is engaging...Biologists will appreciate the breadth of the book and the thorough referencing."--Science"This is a magnificent discussion of the X chromosome function, mechanisms of expression, and the role of the X chromosome in embryogenesis and human pathology.Congratulations are due to Dr. Migeon for a job well done. This is a unique book with very few omissions. Reading it is a pleasure and the author adheres to her goals and provides unique information in a manner I have not seen before. This book has no comparison and I look forward to updated editions." --Doody's Zusammenfassung This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first edition. INTRODUCTION ; PART I BACKGROUND ; CHAPTER 1 SEX DIFFERENCES IN DISEASE ; 1.1. MALES MORE VULNERABLE AT EVERY AGE ; 1.2. VULNERABILITY OF MALES LEADS TO SEX-SPECIFIC DISEASE ; 1.3. SUMMARY AND SPECULATIONS ; CHAPTER 2 EVOLUTION OF THE HUMAN SEX CHROMOSOMES AND A PORTRAIT OF THE HUMAN X ; 2.1. CHROMOSOMAL BASIS OF SEX DETERMINATION ; 2.2. THE HUMAN SEX CHROMOSOMES EVOLVED FROM REPTILIAN AUTOSOMES ; 2.3. DEGENERATION OF THE Y CHROMOSOME ; 2.4. OHNO'S LAW AND THE CONSERVATION OF THE ORIGINAL X ; 2.5. RESIDUAL HOMOLOGY AND THE PSEUDOAUTOSOMAL REGIONS ; 2.6. GENETIC PORTRAIT OF THE HUMAN X ; 2.7. SUMMARY AND SPECULATIONS ; CHAPTER 3 X CHROMOSOME DOSAGE COMPENSATION: AN OVERVIEW ; 3.1. X CHROMOSOME DOSAGE COMPENSATION ; 3.2. HETEROCHROMATIN AND CHROMOSOME SILENCING ; 3.3. ROLE IN SEX DETERMINATION ; 3.4. MECHANISMS OF DOSAGE COMPENSATION IN OTHER ORGANISMS ; 3.5. MECHANISMS OF DOSAGE COMPENSATION IN MAMMALS ; 3.6. SUMMARY AND SPECULATIONS ; CHAPTER 4 THE DISCOVERY OF X CHROMOSOME INACTIVATION ; 4.1. THE LYON HYPOTHESIS ; 4.2. GENERAL SCHEME OF MAMMALIAN DOSAGE COMPENSATION ; 4.3. SUMMARY AND SPECULATIONS ; CHAPTER 5 EXPERIMENTAL MODELS FOR X INACTIVATION STUDIES ; 5.1. SPONTANEOUS HUMAN MUTATIONS THAT INTERFERE WITH INACTIVATION ; 5.2. X-LINKED PROTEIN VARIANTS DISTINGUISH PARENTAL ORIGIN OF X CHROMOSOMES ; 5.3. CHARACTERIZING THE INACTIVE X IN HUMAN CELL CULTURES AND CLONES ; 5.4. ...
