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Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy. The book highlights why it is important that all practicing pharmacists, including those working in hospitals or high street stores, have a solid understanding of the process of the design and development of the drugs they interact with.
It adopts an integrated approach, formulated to complement courses which are designed in line with the General Pharmaceutical Council's new curriculum requirements.
Furthermore, this is the only integrated textbook to consider both drug design and development within one volume. Throughout the book, the journey of the drug, from discovery to market, is presented in an integrated fashion, emphasising the interconnection of all the processes involved.
List of contents
- 1: Introduction
- Part 1 Drug targets
- 2: Receptors and signal transduction
- 3: Enzymes as drug targets
- 4: Nucleic acids and protein synthesis as drug targets
- 5: Other drug targets
- Part 2 Origins of drug molecules
- 6: Sources of lead compounds
- 7: Drug synthesis
- 8: Optimisation of lead compounds
- 9: Computer-aided drug design
- 10: Combinatorial chemistry and high-throughput screening
- 11: Biotechnology and biopharmaceuticals
- Part 3 Biological aspects of drug development
- 12: Drug metabolism
- 13: Pharmacogenetics and pharmacogenomics
- 14: Toxicity testing
- Part 4 Preformulation studies
- 15: Solubility and drug development
- 16: Solid state characteristics
- 17: Drug stability
- Part 5 Clinical research
- 18: Clinical research and its regulation
- 19: Design and management of clinical trials
About the author
Dr Chris Rostron graduated in Pharmacy from Manchester University and completed a PhD in Medicinal Chemistry at Aston University. He gained Chartered Chemist status in 1975. After a period of post-doctoral research he was appointed as a lecturer in Medicinal Chemistry at Liverpool Polytechnic. He is now an Honorary Research Fellow in the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores University. He was a member of the Academic Pharmacy Group Committee of the Royal Pharmaceutical Society of Great Britain and chairman for the past 5 years. He is currently chairman of the Academic Pharmacy Forum and deputy chair of the Education Expert Advisory Panel of the Royal Pharmaceutical Society. He is an external examiner in Medicinal Chemistry at a number of Schools of Pharmacy both in the UK and abroad. In 2008 he was awarded honorary membership of the Royal Pharmaceutical Society of Great Britain for services to Pharmacy education.
Summary
Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy.
Report
Well written text that guides students through the complex elements of the drug development process. It has a chemistry focus and utilises 'key points' to reinforce the important aspects at regular opportunities. Dr James F. Brown, University of Portsmouth
