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This book with provide clinicians with focused reviews on basic sciences to help understanding the mechanisms and treatment of neurologic disease. The chapters emphasize how genetic, molecular and cellular, mechanisms and their interactions control the function of the nervous system and provide the bases for a wide range of neurologic disorders. They include neurodegenerative disorders, epilepsy, movement disorders, peripheral neuropathy, and chronic pain, among others. The chapters contains several figures and tables that summarize the most important concepts
List of contents
- Preface
- Section I: Molecular and Cellular Mechanisms
- Ch1. Overview: Cellular Components of the Nervous System and Disease Mechanisms
- Ch2. Organization of the Cell Membranes
- Ch3. Intracellular Signaling
- Ch4. DNA: Epigenetic Control of Transcription and Repair Mechanisms
- Ch5. RNA Metabolism and Control of Translation
- Ch6. Proteostasis
- Ch7. Vesicular Trafficking
- Ch8. Cytoskeleton
- Ch9. Axonal Transport
- Ch10. Axon and Myelin
- Ch11. Mitochondria and Energy Metabolism
- Ch12. Mechanisms of Cell Death and Axonal Degeneration
- Ch13. Growth Factors, Survival, and Regeneration
- Section II: Excitability, Signal Communication, and Plasticity
- Ch14. Ion Channels and Channelopathies
- Ch15. Principles of Synaptic Transmission and Presynaptic Synaptopahies
- Ch16. Neurotransmission, Neuromodulation, and Plasticity
- Ch17. Glutamatergic Transmission, Plasticity and Synaptopahies
- Ch18. Inhibitory Amino Acid Transmission and Synaptopahies
- Ch19. Cholinergic Transmission
- Ch20. Monoaminergic Neurotransmission
- Section III: Microenvironment and Mechanisms of Injury and repair
- Ch21. Astrocyte-Neuron Interactions
- Ch22. Neuronal Microenvironment
- Ch23. Microglia and Inflammation in the Nervous System
- Section III: Neuronal Interactions in Cortical and Subcortical Circuits
- Ch24. Neocortical Circuits
- Ch25. Hippocampal and Amygdala Circuits
- Ch26. Thalamocortical Interactions
- Ch27. Sleep
- Ch28. Behavioral State Control
- Ch29. Sensory Processing
- Ch30. Cortical Motor Control
- Ch31. Segmental Spinal Motor Control
- Ch32. Brainstem Motor Control
- Ch33. Cerbellum
- Ch34. Basal ganglia
- Section V: Homeostatic Systems
- Ch35. Nociceptors
- Ch36. Central Pain Processing and Modulation
- Ch37. Autonomic Nervous System
- Ch38. Forebrain Control of Homeostasis and Adaptation
- Section VI: Cortical Networks and Cognitive Domains
- Ch39. Emotion and Social Cognition
- Ch40. Episodic Memory, Navigation, and Inner Thoughts
- Ch41. Language, Speech, and Semantic Cognition
- Ch42. Cortical Executive Networks and High-level Behavioral and Cognitive Control
About the author
Eduardo E. Benarroch
Professor of Neurology
Department of Neurology, Mayo Clinic, Rochester, MN
Summary
Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets .
This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.
