Read more
Cardiac amyloidosis (CA) is caused by the accumulation of amyloid fibrils in the extracellular space of the myocardium, with clinical manifestations including conduction disturbances and heart failure. CA has traditionally been considered a rare disease, lacking effective therapies and with a poor prognosis, but in recent years, increased possibilities for non-invasive diagnosis and greater awareness of the disease have led to the identification of a growing number of cases, challenging the concept of CA as a rare disease. This is why the ability to recognise and manage patients with CA should become part of the core curriculum of cardiologists, but also of internal medicine specialists, general practitioners, neurologists, nephrologists and haematologists. This book, written by leading experts in the field, will provide the state-of-the-art in the diagnosis and management of CA and will also discuss the latest research developments and future research directions.
Thevolume appears to be a timely one, given the great interest of clinicians and researchers in CA and the exponential increase in publications in recent year, and will be of interest to cardiologists, internal medicine and other disciplines specialists who may encounter patients with CA in their clinical practice, as well as general practitioners.
List of contents
1. Tribute to Claudio Rapezzi.- 2. Giampaolo Merlini and the Pavia School.- 3. A brief history of amyloidosis.- 4. Pathophysiology, classification and epidemiology of amyloidosis.- 5. Amyloid light chain (AL) amyloidosis.- 6. Hereditary transthyretin amyloidosis.- 7. Wild-type ATTR amyloidosis.- 8. Electrocardiographic patterns.- 9. Echocardiography: a gatekeeper to diagnosis.- 10. Cardiovascular magnetic resonance: characterization of myocardial involvement.- 11. Biomarkers: monoclonal protein and indicators of cardiac damage.- 12. Plasma transthyretin and its ligands.- 13. Cardiac Scintigraphy with Bone-Avid Tracers - Old and New Applications.- 14. PET-CT: a tool for etiological diagnosis.- 15. The role of tissue biopsy: identification of the amyloid precursor and beyond.- 16. From red flags to diagnosis.- 17. Risk prediction and follow-up.- 18. Differential diagnoses in clinical mimics.- 19. Applications of Artificial Intelligence in Amyloidosis.- 20. Treatment of amyloid light-chain amyloidosis.- 21. Treatment of ATTR amyloidosis: from stabilizers to gene-editing.- 22. Treatment of cardiac complications.- 23. Monitoring disease progression and response to disease-modifying treatments.- 24. Cardiac amyloidosis: open issues and future perspectives.
