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Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV).
The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences.
Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures.
List of contents
Chapter 1: Historical Aspects and Biology of Aging
Chapter 2: Cellular and Molecular Determinant of Arterial Aging
Chapter 3: Changing Demography of Europe-Greying Populations
Chapter 4: Population-Based Studies
Chapter 5: Lessons from Amsterdam Growth and Health Longitudinal Study
Chapter 6: History and Findings of the BLSA
Chapter 7: Changes in Peripheral Blood Pressure with Normal and Accelerated Aging
Chapter 8: Changes in Arterial Stiffness with Normal and Accelerated Aging
Chapter 9: Changes in Central Hemodynamics, Wave Reflection and Heart-Vessel Coupling with Normal and Accelerated Aging
Chapter 10: Early Aging of Endothelial Function and Platelet-Vessel Wall Interaction
Chapter 11: The Cross-Talk between the Macro and Microcirculation
Chapter 12: Blood Pressure Variability
Chapter 13: Early Vascular Aging in Children with Low Birth Weight and/or Prematurity
Chapter 14: Age-Induced Endothelial Dysfunction and Intima-Media Thickening
Chapter 15: Glucose Metabolism, Diabetes, and the Arterial Wall
Chapter 16: Chronic Inflammation and Antherosclerosis
Chapter 17: Early and Late Stages of Chronic Kidney Disease in relation to Arterial Changes
Chapter 18: Polycystic Ovarian Syndrome
Chapter 19: Early and Late Stages of Brain Damage
Chapter 20: Telomere Biology and Aging
Chapter 21: Traditional versus new models of Risk Prediction
Chapter 22: Imaging Biomarkers: Aortic Stiffness and Carotid IMT as Predictors of CV Disease
Chapter 23: Genetic Markers in Prediction of CV Disease
Chapter 24: Vascular Aging and CV Disease
Chapter 25: Lifestyle Intervention: What works?
Chapter 26: Targeting BP Lowering and Sympathetic Nervous System
Chapter 27: Targeting Central BP through the Macro-Microcirculation Cross-Talk
Chapter 28: Treatment of Abnormalities in Glucose and Lipid Metabolism
Chapter 29: New Drugs under Development for Cardiovascular Prevention
Chapter 30: Interventions to retard Biological Aging to be Explored
Chapter 31: Immuniziation, Vaccines and Immunomodulation
About the author
Michael Hecht Olsen is a professor in Hypertension and Cardiovascular Prevention at the Department for Regional Health Research, University of Southern Denmark, and senior consultant in cardiology at Department of Medicine 1, Holbaek Hospital, Denmark.
Both clinically and in research, he works with hypertension, obesity, diabetes and cardiovascular risk stratification using measurements of subclinical cardiovascular damage (e.g., pulse wave analysis, ultrasound of the carotid arteries and echocardiography) and new biomarkers for deep phenotyping trying to develop individualized treatment. He has published over 200 publications (Web of Science H-index 47).
Peter M. Nilsson is Senior Professor/expert in Clinical Cardiovascular Research at Lund University, Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden. For many years he has been developing the concept of EVA with numerous colleagues and the prevention of cardiovascular disease and type 2 diabetes.
Stepane Laurent’s research interests are hypertension pathophysiology and management, pharmacology of antihypertensive drugs, arterial stiffness and vascular ageing. He has served as President of the European Society of Hypertension (ESH) (2007-2009) and President of the ARTERY Society (2010-2012), and is the author of over 500 referenced articles and 20 chapters in books.
